| アブストラクト | Insomnia may negatively impact seizure control; however, the corresponding evidence remains limited. This study analyzed the seizure risk associated with various insomnia medications using a comprehensive pharmacovigilance database and identified safe options for patients at high risk of seizures. VigiBase, a database of adverse drug reaction reports from over 140 countries, comprises 35 million reports published from 1967 to 2023. Medications for insomnia include benzodiazepines, Z-drugs, antidepressants, atypical antipsychotics, first-generation H1 antagonists, orexin receptor agonists, melatonin, and melatonin receptor agonists. We assessed the association between insomnia medications and seizure risk by analyzing the reported odds ratio (ROR) with 95% confidence intervals (CI) and the information component (IC) with IC(025). In total, 17,967 cases of seizures associated with insomnia medications were reported, revealing a significant association (ROR, 2.12 [95% CI, 2.09 to 2.15]; IC, 1.05 [IC(025), 1.03]). Based on the mechanism of action, seizures were significantly associated with benzodiazepines (ROR, 2.56 [95% CI, 2.49 to 2.64]; IC, 1.34 [IC(025), 1.29]), Z-drugs (ROR, 1.58 [1.49 to 1.69]; IC, 0.66 [0.56]), antidepressants (ROR, 2.52 [2.43 to 2.61]; IC, 1.32 [1.26]), atypical antipsychotics (ROR, 1.92 [1.88 to 1.97]; IC, 0.93 [0.89]), first-generation H1 antagonists (ROR, 2.08 [1.98 to 2.19]; IC, 1.05 [0.96]), and melatonin (ROR, 1.81 [1.49 to 2.20]; IC, 0.84 [0.51]). In contrast, orexin receptor antagonists (ROR, 0.81 [95% CI, 0.61 to 1.07]; IC, - 0.30 [IC(025), - 0.77]) and melatonin receptor agonists (ROR, 1.20 [0.80 to 1.81]; IC, 0.26 [- 0.44]) showed no significant association with seizures. Although the disproportionality analysis did not allow causal interpretation, our study highlights significant variations in seizure signal among insomnia medications. |
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| ジャーナル名 | Scientific reports |
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| Pubmed追加日 | 2025/7/28 |
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| 投稿者 | Kim, Tae Hyeon; Lee, Kyeongmin; Hwang, Jiyoung; Lee, Suhyun; Jo, Hyesu; Cho, Hanseul; Lee, Hayeon; Baek, Hye Jeong; Kang, Jiseung; Nehs, Christa J; Fond, Guillaume; Boyer, Laurent; Chung, Eun Kyoung; Yon, Dong Keon |
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| 組織名 | Department of Precision Medicine, Kyung Hee University College of Medicine,;Seoul, South Korea.;Center for Digital Health, Medical Science Research Institute, Kyung Hee;University Medical Center, Kyung Hee University College of Medicine, 23;Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.;Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul,;South Korea.;Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, South;Korea.;Department of Electronics and Information Convergence Engineering, Kyung Hee;University, Yongin, South Korea.;School of Health and Environmental Science, College of Health Science, Korea;University, Seoul, South Korea.;Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.;Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General;Hospital, Boston, MA, USA.;CEReSS-Health Service Research and Quality of Life Center, Assistance;Publique-Hopitaux de Marseille, Aix Marseille University, Marseille, France.;South Korea. cekchung@khu.ac.kr.;Korea. cekchung@khu.ac.kr.;Department of Pharmacy, Kyung Hee University Hospital, Gangdong , Seoul, South;Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul,;Department of Pharmacy, College of Pharmacy, Department of Regulatory Science,;Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul,;02447, Republic of Korea. cekchung@khu.ac.kr.;Seoul, South Korea. yonkkang@gmail.com.;Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea. yonkkang@gmail.com.;South Korea. yonkkang@gmail.com.;Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee;University College of Medicine, Seoul, South Korea. yonkkang@gmail.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40715268/ |
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