| アブストラクト | BACKGROUND: Aromatase inhibitors (AIs) are commonly used to treat postmenopausal hormone receptor positive breast cancer, but there is currently a lack of comprehensive safety reports on AIs in large-scale cohorts. RESEARCH DESIGN AND METHODS: We conducted a retrospective pharmacovigilance survey based on the FDA Adverse Event Reporting System, retrieving relevant reports from the 2004 to the 2023, aiming to conduct a comprehensive comparative analysis of adverse reactions associated with AIs. In addition, we elucidated the potential toxicological mechanisms of AIs related adverse events through functional enrichment analysis. RESULTS: A total of 7,933 adverse event reports related to AIs were collected, and there were 642 positive signals at the preferred term level. The top three signal intensities for anastrozole are: antiphospholipid syndrome, plantar fasciitis and autoimmune pancreatitis. The top three signal intensities for letrozole are: androgenetic alopecia and myosclerosis, pneumonic herpes virus. The top three signal intensities for exemestane are: infection reactivation, thyroxine free decreased and dilatation atrial. In terms of onset time, letrozole has the earliest onset time overall, followed by exemestane, and finally anastrozole. CONCLUSIONS: Our research corroborates the typical adverse events linked to AIs while highlighting potential safety concerns in their real-world clinical application. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2024/11/5 |
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| 投稿者 | Zhang, Si-Qi; Jia, Shujing; Li, Xiang; Hu, Rui-Rui; Luo, Zhanyang; Wang, Junhai; Xi, Hongyan |
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| 組織名 | Department of Clinical Laboratory, Handan First Hospital, Handan, China.;Department of Oncology, Xiang'an Hospital of Xiamen University, School of;Medicine, Xiamen University, Xiamen, China.;Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory;of Ophthalmology and Visual Science; Fujian Engineering and Research Center of;Eye Regenerative Medicine, Eye Institute of Xiamen University; School of;Medicine, Xiamen University, Xiamen, Fujian, China.;State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye;Hospital, Wenzhou Medical University, Wenzhou, China.;Department of Pharmacy, Shanghai Pudong Hospital, Fudan University Pudong Medical;Center, Shanghai, China.;Department of Obstetrics and Gynecology, Yancheng TCM Hospital Affiliated to;Nanjing University of Chinese Medicine; Yancheng TCM Hospital, Jiangsu, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39497024/ |
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