| アブストラクト | BACKGROUND: Celecoxib is now clinically recognized as a candidate for treating various neurological disorders and cancers. The recent emergence of some serious adverse reactions is concerning. RESEARCH DESIGN AND METHODS: We carried out data mining on the FDA Adverse Event Reporting System (FAERS) for adverse events (AEs) with celecoxib as the main suspect drug and conducted a disproportionality analysis. RESULTS: 111,155,092 AE reports were extracted from FAERS, and 32,841 AEs with celecoxib as the primary suspected drug were identified. Celecoxib AEs were predominantly reported in cardiac disorders (n = 9602) and nervous system disorders (n = 4045). Cerebrovascular accident (n = 3109, PRR = 3.24) ranked second in the number of reports and cerebrovascular disorder (n = 265, PRR = 5.06) ranked second in signal intensity, was described as rare in the instructions. Nine unexpected and serious AEs were discovered, such as Stevens-Johnson syndrome (n = 175, IC025 = 1.7), breast disease male (n = 4, IC025 = 1.54), and squamous cell carcinoma of the head and neck (n = 4, IC025 = 0.96). At 200 mg, celecoxib was more linked to musculoskeletal and connective AEs; At 400 mg, it was more linked to neurological and cardiovascular AEs. CONCLUSIONS: Unexpected AEs of celecoxib in neurological diseases and cancer have been identified, offering valuable insights for monitoring and risk assessment in future clinical applications. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2025/3/31 |
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| 投稿者 | Du, Yikuan; Zhang, Mengting; Chen, Mianhai; Hu, Mianda; Zeng, Wenqi; Cai, Xiaolin; Zhang, Weichui; Zhu, Jinfeng; Zhong, Mingjun; Liu, Yi; Yang, Chun |
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| 組織名 | Central Laboratory, The Tenth Affiliated Hospital of Southern Medical University,;Dongguan, China.;Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The;First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong;Medical University, Dongguan, China.;The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan,;China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40159988/ |
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