| アブストラクト | BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination. RESEARCH DESIGN AND METHODS: This study included a comprehensive evaluation of AE cases covered PD-1/PD-L1 inhibitors-SSRIs combination (first quarter of 2004 to second quarter of 2024) using the FDA Adverse Event Reporting System (FAERS) database, and compared with the use of PD-1/PD-L1 inhibitors or SSRIs alone. RESULTS: By extracting a total of 807 reports of related AEs, the combination therapy was associated with a distinct AE profile characterized by an increased incidence of immune-related and systemic disorders, as well as a higher signal for adverse pregnancy and perinatal outcomes. CONCLUSIONS: This study represents the largest report to date on PD-1/PD-L1 inhibitors-SSRIs -related AEs, providing valuable insights into the potential side effects of SSRIs for cancer patients with depression. Clinicians should exercise caution when prescribing SSRIs alongside PD-1/PD-L1 inhibitors, particularly in vulnerable populations such as pregnant women and those with significant comorbidities. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2024/12/23 |
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| 投稿者 | Dong, Jiaqi; Liu, Mingyue; Li, Suning; Zhang, Siqi; Fu, Pengbin; Liu, Mengya; Jin, Shasha; Fan, Chunliang; Fang, Mingzhu; Wu, Liang; Li, Zhe |
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| 組織名 | School of Medicine, Department of Xiangan Hospital of Xiamen University, Xiamen,;China.;Department of Sports Rehabilitation, Beijing Xiaotangshan Hospital, Beijing,;Department of Respiratory Diseases, Tongji Hospital, Tongji Medical College,;Huazhong University of Science and Technology, Wuhan, Hubei, China.;Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Zhengzhou;University, Zhengzhou, China.;Henan Rehabilitation Clinical Medicine Research Center, Zhengzhou, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39714905/ |
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