| アブストラクト | BACKGROUND: There have been limited studies examining age-dependent associations between physical inactivity and cardiovascular disease (CVD). We aimed to clarify the age-dependent relationship of physical inactivity with incident CVD. METHODS: We analyzed 1,097,424 participants, aged 18 to 105 years, without histories of CVD, enrolled in the DeSC database (median age, 63 years; 46.4% men). We categorized participants into the following 4 groups based on age: </= 44 years (n = 203,835); 45 to 64 years (n = 403,619); 65 to 79 years (n = 437,236); and >/= 80 years (n = 52,734). We used 3 physical inactivity components gained from the self-reported questionnaire during a health checkup. The outcomes were composite CVD events including myocardial infarction, stroke, heart failure, and each CVD event. RESULTS: During a mean follow-up of 3.2 +/- 1.9 years, 81,649 CVD events were observed. The hazard ratios of 3 physical inactivity components for CVD events increased with age category (P for interaction < 0.001). For example, the hazard ratio (95% confidence interval) of physical inactivity defined as not doing light sweaty exercise for 30 minutes at least twice a week for incident CVD in the groups aged </= 44 years, 45 to 64 years, 65 to 79 years, and >/= 80 years were 0.97 (0.88-1.05), 1.08 (1.05-1.12), 1.12 (1.10-1.15), and 1.17 (1.12-1.21), respectively (P for interaction < 0.001). This association was consistent across subtypes of CVD including heart failure, myocardial infarction, and stroke. CONCLUSIONS: The association of physical inactivity with a higher risk of developing CVD increased with age. Preventive efforts for physical activity optimization may be more valuable in older people. |
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| ジャーナル名 | The Canadian journal of cardiology |
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| 投稿日 | 2024/6/22 |
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| 投稿者 | Ueno, Kensuke; Kaneko, Hidehiro; Kamiya, Kentaro; Suzuki, Yuta; Okada, Akira; Takeda, Norifumi; Fujiu, Katsuhito; Morita, Hiroyuki; Ako, Junya; Node, Koichi; Yasunaga, Hideo; Komuro, Issei |
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| 組織名 | The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan;;Department of Rehabilitation Sciences, Graduate School of Medical Sciences,;Kitasato University, Kanagawa, Japan.;The Department of Advanced Cardiology, The University of Tokyo, Tokyo, Japan.;Electronic address: kanekohidehiro@gmail.com.;Department of Rehabilitation, School of Allied Health Sciences, Kitasato;University, Kanagawa, Japan.;The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.;Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate;School of Medicine and The Department of Health Services Research, The University;of Tokyo, Tokyo, Japan.;Department of Cardiovascular Medicine, School of Medicine, Kitasato University,;Kanagawa, Japan.;Department of Cardiovascular Medicine, Saga University, Saga, Japan.;The Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Tokyo, Japan.;Department of Frontier Cardiovascular Science, The University of Tokyo, Tokyo,;Japan; International University of Health and Welfare, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38906248/ |
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