| アブストラクト | Tumor necrosis factor-alpha (TNF-alpha) inhibitors are increasingly being used as treatment for rheumatoid arthritis (RA). However, the administration of these drugs carries the risk of inducing injection site reaction (ISR). ISR gives rise to patient stress, nervousness, and a decrease in quality of life (QoL). In order to alleviate pain and other symptoms, early countermeasures must be taken against this adverse event. In order to improve understanding of the risk factors contributing to the induction of ISR, we evaluated the association between TNF-alpha inhibitors and ISR by applying a logistic regression model to age-stratified data obtained from the Food and Drug Administration Adverse Event Reporting System (FAERS) database. The FAERS database contains 7,561,254 reports from January 2004 to December 2015. Adjusted reporting odds ratios (RORs) (95% Confidence Intervals) were obtained for interaction terms for age-stratified groups treated with etanercept (ETN) and adalimumab (ADA). The adjusted RORs for ETN* >/= 70 and ADA* >/= 70 groups were the lowest among the age-stratified groups undergoing the respective monotherapies. Furthermore, we found that crude RORs for ETN + methotrexate (MTX) combination therapy and ADA + MTX combination therapy were lower than those for the respective monotherapies. This study was the first to evaluate the relationship between aging and ISR using the FAERS database. |
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| 投稿者 | Matsui, Toshinobu; Umetsu, Ryogo; Kato, Yamato; Hane, Yuuki; Sasaoka, Sayaka; Motooka, Yumi; Hatahira, Haruna; Abe, Junko; Fukuda, Akiho; Naganuma, Misa; Kinosada, Yasutomi; Nakamura, Mitsuhiro |
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| 組織名 | Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4;Daigaku-nishi, Gifu, 501-1196, Japan.;Daigaku-nishi, Gifu, 501-1196, Japan;; Clinical Research, Innovation and;Education Center, Tohoku University Hospital, 1-1, Seiryomachi, Aoba-ku, Sendai,;Miyagi, 980-8574, Japan.;Daigaku-nishi, Gifu, 501-1196, Japan;; Medical Database Co., LTD, 3-11-10;Higashi, Shibuya-ku, Tokyo, 150-0011, Japan.;United Graduate School of Drug Discovery and Medical Information Sciences, Gifu;University, 1-1 Yanagido, Gifu, 501-1194, Japan. |
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