| アブストラクト | AIMS/HYPOTHESIS: The aim of this work was to determine how weight patterns together with blood glucose, BP and lipids vary at diagnosis of diabetes by age, sex and ethnicity. METHODS: Using the UK Clinical Practice Research Datalink, we identified people with type 2 diabetes (n = 187,601) diagnosed in 1998-2015 and compared their weights, HbA(1c), BP and lipid levels at diagnosis with age-matched people without diabetes (n = 906,182), by sex and ethnic group. RESULTS: Younger age at diagnosis was associated with greater adjusted mean difference (95% CI) in weight between those with vs without type 2 diabetes: 18.7 (18.3, 19.1) kg at age 20-39 years and 5.3 (5.0, 5.5) kg at age >/= 80 years. Weight differentials were maximal in white women, and were around double in white people compared with South Asian and black people. Despite lower absolute values, BP differences were also greater at younger age of diabetes onset: 7 (6, 7) mmHg at age 20-39 years vs -0.5 (-0.9, -0.2) at age >/= 80 years. BP differences were greatest in white people, and especially in women. Triacylglycerol level differences were greatest in younger men. Finally, HbA(1c) levels were also higher with younger onset diabetes, particularly in black people. CONCLUSIONS/INTERPRETATION: At diagnosis of type 2 diabetes, when compared with people without diabetes, weight and BP differentials were greater in younger vs older people, in women vs men and in white vs South Asian and black people. These differences were observed even though South Asian and black people tend to develop diabetes a decade earlier with either similar or greater dysglycaemia. These striking patterns may have implications for management and prevention. Graphical abstract. |
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| ジャーナル名 | Diabetologia |
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| Pubmed追加日 | 2020/5/22 |
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| 投稿者 | Wright, Alison K; Welsh, Paul; Gill, Jason M R; Kontopantelis, Evangelos; Emsley, Richard; Buchan, Iain; Ashcroft, Darren M; Rutter, Martin K; Sattar, Naveed |
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| 組織名 | Division of Diabetes, Endocrinology and Gastroenterology, School of Medical;Sciences, University of Manchester, Manchester, UK.;Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and;Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre,;University of Manchester, Manchester, UK.;Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular;Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA,;UK.;Division of Population Health, Health Services & Primary Care, School of Health;Department of Biostatistics & Health Informatics, Institute of Psychiatry,;Psychology and Neuroscience, King's College London, London, UK.;Department of Public Health and Policy, Institute of Population Health Sciences,;University of Liverpool, Liverpool, UK.;Manchester Diabetes Centre, Manchester Academic Health Sciences Centre,;Manchester University NHS Foundation Trust, Manchester, UK.;UK. naveed.sattar@glasgow.ac.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32435821/ |
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