| アブストラクト | BACKGROUND: Mortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population. AIM: To determine the overall survival in patients with cirrhosis compared with the general population taking into account the effects of severity and aetiology of disease and comorbidity. METHODS: In a cohort study, we identified 4537 people with cirrhosis and a control cohort of 44 403 patients, matched by age, sex and general practice from the UK General Practice Research Database between June 1987 and April 2002. RESULTS: Patients with compensated cirrhosis had a nearly five-fold [hazard ratio (HR) 4.7, 95% confidence interval (CI) 4.4-5.0] increased risk of death, while those with decompensated cirrhosis had a near 10-fold (HR 9.7, 95% CI 8.9-10.6) increased risk compared with the general population. Alcoholic cirrhosis conferred a worse prognosis than non-alcohol-related cirrhosis both in the first year following diagnosis and subsequently. CONCLUSION: Having a diagnosis of cirrhosis confers a substantial increased mortality risk compared with the general population, even for those with compensated disease, with 5-year survival between that seen for breast and colorectal cancer. |
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| ジャーナル名 | Liver international : official journal of the International Association for the Study of the Liver |
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| Pubmed追加日 | 2011/7/13 |
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| 投稿者 | Fleming, Kate M; Aithal, Guruprasad P; Card, Tim R; West, Joe |
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| 組織名 | Division of Epidemiology and Public Health, University of Nottingham, Nottingham,;UK. kate.fleming@nottingham.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/21745279/ |
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