| アブストラクト | BACKGROUND: The use of herbal medicines in children and the general population is continually on the rise with an overall herbal lifetime and current use ranging between 0.8%-85.5% and 2.2%-8.9%, respectively. Although acute hypersensitivity reactions are generally considered to be rare, little knowledge exists on the frequency and type of these reactions especially in specific populations like children. OBJECTIVES: To assess the patterns of acute hypersensitivity reactions to herbal medicines reported to the WHO global individual case safety report (ICSR) database VigiBase((R)) in children. STUDY DESIGN: From the original VigiBase((R)) extract for the time between 1968 and 2014, we included all reports with adverse drug reactions (ADR) associated with herbal medicines in children where WHO-ART reaction terms were indicative of acute hypersensitivity reactions. RESULTS: VigiBase((R)) contained 2646 ICSRs with 14 860 distinct adverse reactions reported in association with herbal medicine in children. Among those, 79 cases with 107 allergy-like reactions met our inclusion criteria. The most commonly reported WHO-ART terms were urticaria or rash/rash erythematous (59.8%), and allergic reaction (8.4%). The most frequently reported suspected herbal medicines were mixed herbal products (51.4%), Hedera helix (15.0%), and Echinacea purpurea (5.6%). Most frequent routes of administration were oral (75.9%), topical (8.9%), and rectal (3.8%). Over 30% of cases were reported in the age group from 7 to 12 years. The majority of reports were received from Germany (29.1%), Thailand (21.5%), and Australia (11.4%). CONCLUSION: VigiBase((R)) contains a considerable number of acute hypersensitivity reactions in children associated with herbal medicines, including life-threatening reactions such as anaphylactic shock. |
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| ジャーナル名 | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology |
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| 投稿日 | 2017/08/29 |
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| 投稿者 | Meincke, Ricarda; Pokladnikova, Jitka; Straznicka, Julie; Meyboom, Ronald H B; Niedrig, David; Russmann, Stefan; Jahodar, Ludek |
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| 組織名 | Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Charles;University in Prague, Hradec Kralove, Czech Republic.;WHO Collaborating Centre for International Drug Monitoring, Uppsala Monitoring;Centre, Uppsala, Sweden.;Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht University,;Utrecht, The Netherlands.;University Children's Hospital Zurich, Zurich, Switzerland.;drugsafety.ch, Kusnacht, Switzerland.;Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.;Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28846157/ |
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