| アブストラクト | BACKGROUND: Alopecia is associated with erenumab post-marketing, but no cases have been described. METHODS: We describe two patients that reported temporary hair loss and review the FDA Adverse Event Reporting System (FAERS). RESULTS: The first patient experienced alopecia within three months of starting erenumab, which did not improve with ongoing use or transition to fremanezumab. The second patient reported alopecia within two weeks of starting erenumab, which continued after transition to galcanezumab; months later, there was also recurrent hair loss within one month of starting fremanzeumab. According to FAERS (last accessed 18 August 2022), alopecia was reported most with erenumab (1158), followed by galcanezumab (554), fremanezumab (175), eptinezumab (23), rimegepant (26), ubrogepant (4), and atogepant (3). CONCLUSION: Most events were reported in women and non-serious. The potential mechanism of alopecia with drugs targeting calcitonin gene-related peptide or its receptor possibly includes disruptions in the microvascular circulation and other homeostatic mechanisms. |
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| ジャーナル名 | Cephalalgia : an international journal of headache |
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| 投稿日 | 2023/2/6 |
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| 投稿者 | Ruiz, Miguel; Cocores, Alexandra; Tosti, Antonella; Goadsby, Peter J; Monteith, Teshamae S |
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| 組織名 | Department of Biological Sciences, Florida International University, Miami,;Florida, USA.;Department of Neurology, Division of Headache, University of Miami Miller School;of Medicine, Miami, Florida, USA.;Department of Dermatology and Cutaneous Surgery, University of Miami Miller;School of Medicine, Miami, Florida, USA.;Institute of Psychiatry, Psychology, And Neuroscience, King's College, London,;UK.;Department of Neurology, University of California, Los Angeles, California, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36739513/ |
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