| アブストラクト | Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treatment of type 2 diabetes mellitus (T2DM), have been approved for the treatment of obesity in patients with or without T2DM (liraglutide-LIR, semaglutide-SEM, and tirzepatide-TIR). Social media had an important influence on the off-label use of GLP-1 RAs for obesity, especially for SEM. We analyzed the Google queries related to SEM to assess people's interest in this drug. We also investigated the occurrence of adverse drug reactions (ADRs) by searching the EudraVigilance database (EV) for Individual Case Safety Reports (ICSRs) that reported SEM as the suspected drug and performed a descriptive and a disproportionality analysis. The data obtained for SEM were compared to other GLP-1 RAs. SEM had the highest proportions of searches on Google associated with the term "weight loss" and presented the lowest number of severe ADRs, but it also had the highest number of ICSRs reported in EV. Even though no unexpected safety issues have been reported for it until now, SEM has a hi3gh tendency for overdose reports. The most frequent off-label use was reported for SEM and TIR. In order to lower the risks of ADRs, the off-label use should be reduced and carefully monitored. |
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| ジャーナル名 | Biomedicines |
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| 投稿日 | 2024/5/25 |
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| 投稿者 | Butuca, Anca; Dobrea, Carmen Maximiliana; Arseniu, Anca Maria; Frum, Adina; Chis, Adriana Aurelia; Rus, Luca Liviu; Ghibu, Steliana; Juncan, Anca Maria; Muntean, Andrei Catalin; Lazar, Antonina Evelina; Gligor, Felicia Gabriela; Morgovan, Claudiu; Vonica-Tincu, Andreea Loredana |
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| 組織名 | Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu,;2A Lucian Blaga St., 550169 Sibiu, Romania.;Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy,;"Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca,;Romania.;National Institute of Research and Development for Electrochemistry and Condensed;Matter, 144 Dr. A. P. Podeanu, 300569 Timisoara, Romania. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38791086/ |
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