| アブストラクト | In the last decades the increasing rate of obesity in children and adolescents worldwide has led to the onset in paediatric age of metabolic syndrome, a disease commonly associated to adulthood. Central obesity, dyslipidaemia, hyperglycaemia, and hypertension are typical features of metabolic syndrome that seem to hesitate often in type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and many other clinical conditions. Thus preventing and curing metabolic syndrome in paediatric patients is becoming an urgent need for public health. While diagnostic criteria and therapy of metabolic syndrome in adults are very well defined, there is no consensus on the definition of metabolic syndrome in children and adolescents as well as on healing approaches. The aim of this review is to describe the recent advances on the pathogenesis and clinical outcomes of paediatric metabolic syndrome. We then detail the therapeutic strategies (i.e. dietary regimens, physical exercise, nutraceuticals, and medications) employed to manage the disease. Finally, we analyse the safety profile of the drugs used in children and adolescents by performing a retrospective review of paediatric adverse reactions reported in the FDA's Adverse Event Reporting System database. |
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| ジャーナル名 | Pharmacological research |
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| Pubmed追加日 | 2017/1/24 |
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| 投稿者 | Mameli, Chiara; Zuccotti, Gian Vincenzo; Carnovale, Carla; Galli, Erica; Nannini, Pilar; Cervia, Davide; Perrotta, Cristiana |
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| 組織名 | Department of Paediatrics, V. Buzzi Hospital, Universita degli Studi di Milano,;Milano, Italy.;Department of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Universita;degli Studi di Milano, Italy.;degli Studi di Milano, Italy; Department for Innovation in Biological, Agro-Food;and Forest Systems (DIBAF), Universita degli Studi della Tuscia, Viterbo, Italy.;degli Studi di Milano, Italy. Electronic address: cristiana.perrotta@unimi.it. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28111263/ |
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