| アブストラクト | BACKGROUND: The association between anti-dementia drugs and arrhythmia is uncertain. In addition, the effects of certain drug combinations are not yet well known. OBJECTIVE: We investigated the association between anti-dementia drugs and arrhythmia. Furthermore, we investigated the effects of anti-dementia drugs both alone and in combination on the likelihood of arrhythmia in patients with dementia. METHODS: We examined the Japanese Adverse Drug Event Report database (JADER) from April 2004 to May 2022 for dementia drug users aged >/= 60 years. We calculated the unadjusted reported odds ratio (ROR) and adjusted ROR for confounding factors. Furthermore, we examined the association of various combinations of anti-dementia drugs with the development of arrhythmias. RESULTS: There were 6718 arrhythmia cases identified out of 333,702 reported cases. The unadjusted ROR results were as follows: donepezil alone (ROR 4.39, 95% confidence interval [CI] 3.89-4.95), rivastigmine alone (2.10, 1.53-2.87), galantamine alone (3.87, 3.04-4.94), memantine alone (2.25, 1.59-3.20), and combination of choline esterase inhibitor and memantine (2.56, 1.84-3.57). In a multivariate analysis, the RORs remained significant. CONCLUSIONS: Regardless of whether anti-dementia drugs were used alone or in combination, attention should be paid to the occurrence of arrhythmias. |
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| ジャーナル名 | Drugs - real world outcomes |
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| 投稿日 | 2023/4/22 |
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| 投稿者 | Kobayashi, Shotaro; Sugama, Norio; Nagano, Hiroyuki; Miyamori, Ayaka; Takahashi, Masahiro; Kushiyama, Akifumi |
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| 組織名 | Department of Pharmacy, Sonoda Daiichi Hospital, Tokyo, Japan.;Department of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose, Tokyo,;204-8588, Japan.;Department of Pharmacy, Saitama Medical University Hospital, Saitama, Japan.;Department of Pharmacy, National Hospital Organization Chiba Medical Center,;Chiba, Japan.;204-8588, Japan. kushiyama@my-pharm.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37086360/ |
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