| アブストラクト | OBJECT: The appropriate use of antiemetics is important for the prevention of chemotherapy-induced nausea and vomiting (CINV); however, little is known about the rate of concordance with antiemetic guidelines for CINV in the field of pediatric, adolescent, and young adult. METHODS: Using the Diagnosis Procedure Combination system in Japan, we identified patients <30 years of age who were diagnosed with cancer between July 2010 and March 2016. We have assessed concordance with the ASCO antiemetic guidelines for each emetic risk category of chemotherapeutic drugs. Furthermore, we have assessed the risk factors of discordance with the antiemetic guidelines using a logistic regression. RESULTS: In total, 21 106 patients who underwent chemotherapy were included. The rates of concordance with the guidelines in each emetic risk category of chemotherapeutic drugs were 51.1% in high risk, >/=18 years of age; 21.5% in high risk, <18 years of age; 32.1% in moderate risk; 52.0% in low risk; and 51.6% in minimal risk. The main reason for the discordance was underuse of antiemetics, especially steroids. The factors for discordance were younger age, use of moderate and high emetic risk chemotherapeutic drugs, hematological malignancy, and brain tumor. CONCLUSION: There is substantial scope to improve the antiemetic practice and reduce the risk of discordance with the antiemetic guidelines in pediatric, adolescent, and young adult patients. The risk factors are different from those in adults. Further investigations to evaluate the causes of discordance are warranted. |
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| ジャーナル名 | Cancer medicine |
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| 投稿日 | 2019/8/31 |
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| 投稿者 | Bun, Seiko; Kunisawa, Susumu; Sasaki, Noriko; Fushimi, Kiyohide; Matsumoto, Kimikazu; Yamatani, Akimasa; Imanaka, Yuichi |
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| 組織名 | Department of Healthcare Economics and Quality Management, Graduate School of;Medicine, Kyoto University, Kyoto, Japan.;Department of Pharmacy, National Center for Child Health and Development;Hospital, Setagaya-ku, Japan.;Department of Health Policy and Informatics, Graduate School of Medicine, Tokyo;Medical and Dental University, Bunkyo-ku, Japan.;Department of Children's Oncology Center, National Center for Child health and;Development Hospital, Setagaya-ku, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31469518/ |
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