| アブストラクト | BACKGROUND: Evaluating antibiotics most commonly associated with pseudomembranous colitis (PMC) based on the real-world data is of great significance. RESEARCH DESIGN AND METHODS: We used the data from FAERS to evaluate the potential association between antibiotics and PMC by disproportionality analyzes. RESULTS: Eighty-one antibiotics which met the three algorithms simultaneously were enrolled. There were 1683 reports of PMC associated with the enrolled antibiotics. In the top 24 antibiotics, cefoxitin, streptomycin, fosfomycin, and micafungin had a high risk of PMC, but there were few reports in the literature. CONCLUSIONS: This study was of great significance for healthcare professionals to realize the potential PMC risks of antibiotics. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2024/4/11 |
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| 投稿者 | Chen, Jinhua; Yu, Weijiang; Zhang, Wancun; Sun, Cuicui; Zhang, Wenzhou |
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| 組織名 | Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University &;Henan Cancer Hospital, Henan Engineering Research Center for Tumor Precision;Medicine and Comprehensive Evaluation, Henan Provincial Key Laboratory of;Anticancer Drug Research, Zhengzhou, China.;Health Commission of Henan Province Key Laboratory for Precision Diagnosis and;Treatment of Pediatric Tumor, Department of Pediatric Oncology Surgery,;Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.;Department of Pharmacy, Qilu Hospital of Shandong University, Ji'nan, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38603461/ |
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