| アブストラクト | Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Using population-representative UK primary care records, we defined three autistic groups-autistic adults with intellectual disability (ID), autistic adults without ID and all autistic adults-and four non-autistic groups. In each calendar year we calculated: annual, lifetime and new antidepressant prescribing; indications for serotonin-selective reuptake inhibitor initiation; average doses prescribed for citalopram, fluoxetine, and sertraline; and the proportion of courses that lasted over 1, 2, and 3 years. We also repeated analyses with sex-stratification. In all, 34,173,295 non-autistic adults and 172,242 autistic adults were included (47,011 with ID and 125,231 without ID). 30% of autistic adults and 14.7% of non-autistic adults were prescribed an antidepressant in 2023. Prescriptions, doses and course durations increased over time for all groups. Prescriptions were highest in autistic adults without ID and females, whereas course durations were highest in autistic adults with ID. Recording of depression and anxiety as indications was lower for those with ID. Antidepressant prescribing has increased more for autistic adults than non-autistic adults since 1997, with more new starters, higher doses and longer course durations. This potentially increases the risk of adverse medication effects for autistic adults and emphasizes the need for stronger evidence around the effectiveness and tolerability of mental health interventions and the reasons for systematic differences in prescribing. |
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| ジャーナル名 | Autism research : official journal of the International Society for Autism Research |
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| Pubmed追加日 | 2026/8/27 |
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| 投稿者 | Sadik, Aws; Khandaker, Golam M; Pardinas, Antonio F; Lundberg, Michael; Lee, Brian K; Magnusson, Cecilia; Rai, Dheeraj; Madley-Dowd, Paul |
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| 組織名 | MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical;School, University of Bristol, Bristol, UK.;Centre for Academic Mental Health, Population Health Sciences, Bristol Medical;Avon and Wiltshire Mental Health Partnership NHS Trust, Bristol, UK.;NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston;NHS Foundation Trust, Bristol, UK.;NIHR Bristol Clinical Research Facility, University Hospitals Bristol and Weston;Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological;Medicine and Clinical Neurosciences, School of Medicine, Cardiff University,;Cardiff, UK.;Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.;A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania, USA.;Department of Epidemiology and Biostatistics, Drexel University Dornsife School;of Public Health, Philadelphia, Pennsylvania, USA.;Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm,;Sweden.;NIHR Applied Health Collaboration South West, Bristol, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42658004/ |
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