| アブストラクト | STUDY OBJECTIVE: To estimate and compare the prevalence of congenital anomalies among the offspring of women exposed and not exposed to antidepressants during early pregnancy. DESIGN: Matched cohort study. DATA SOURCE: United Kingdom's General Practice Research Database. SUBJECTS: Women exposed to tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants during the first trimester of pregnancy (3276 women) and a sample of women matched in a 2:1 ratio who had no exposure to any antidepressant during the first trimester of pregnancy (6617 women). MEASUREMENTS AND MAIN RESULTS: The prevalence of any congenital anomaly was 31.0 (95% confidence interval [CI] 27.0-35.5) per 1000 pregnancies among women not exposed to antidepressants and 27.2 (95% CI 22.1-33.4) per 1000 pregnancies among women exposed to antidepressants. The relative risk of having a child with an anomaly in mothers who were exposed to tricyclics and SSRIs during the first trimester compared with mothers not exposed to these drugs was 0.9 (95% CI 0.7-1.1). The relative risks for any anomaly among women exposed to antidepressants were 0.9 (95% CI 0.6-1.2) for tricylics and 0.9 (95% CI 0.7-1.2) for SSRIs. We found no statistically significant, stable increases in the risk of specific anomaly subtypes among women exposed to these antidepressants; however, the number of exposed cases was small. CONCLUSION: Exposure to tricyclics and SSRIs during the first trimester of pregnancy was not associated with a statistically significant increased risk of congenital anomalies in the offspring of mothers exposed to these drugs. |
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| ジャーナル名 | Pharmacotherapy |
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| 投稿日 | 2013/6/8 |
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| 投稿者 | Vasilakis-Scaramozza, Catherine; Aschengrau, Ann; Cabral, Howard; Jick, Susan S |
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| 組織名 | Department of Epidemiology, Boston University School of Public Health, Boston,;Massachusetts, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/23744675/ |
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