| アブストラクト | Recent research suggests that fetal exposure to antidepressants (ADs) is significantly associated with fetal death, including stillbirth. However, there has been limited investigation into the timing of AD exposure during pregnancy, the specific effect of each drug, and the possibility of indication bias. To address these gaps in knowledge, we conducted a systematic review of literature and disproportionality analyses using the WHO Safety Database (VigiBase(ⓁE). The systematic review provided evidence for increased risks of fetal death with exposure to any selective serotonin reuptake inhibitor (SSRI) at any time of pregnancy, stillbirth with exposure to any AD during the first trimester, and stillbirth with exposure to any SSRI during the first trimester. Disproportionality analyses revealed significant associations with citalopram, clomipramine, paroxetine, sertraline, and venlafaxine. Combining both sets of results, we conclude that exposure to ADs, especially during the first trimester of pregnancy, seems to be associated with fetal mortality, and that ADs with highest placental transfer may be particularly involved. Further research should investigate the links between ADs during early pregnancy and fetal mortality. |
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| ジャーナル名 | Psychiatry research |
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| 投稿日 | 2024/7/4 |
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| 投稿者 | Desaunay, Pierre; Eslier, Maxime; Alexandre, Joachim; Dreyfus, Michel; Chretien, Basile; Guenole, Fabian |
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| 組織名 | Centre Hospitalier Universitaire de Caen Normandie, service de psychiatrie de;l'enfant et de l'adolescent, Avenue de la cote de nacre, 14000, Caen, France.;Polyclinique du Parc, service de gynecologie et d'obstetrique, 20 Avenue du;Capitaine Georges Guynemer, 14000, Caen, France; Center for Research on;Epidemiology and Statistics Sorbonne Paris Cite, Obstetrical Perinatal and;Pediatric Epidemiology Research Team, 10 Avenue de Verdun, 75010, Paris, France.;Centre Hospitalier Universitaire de Caen Normandie, service de pharmacologie,;Avenue de la cote de nacre, 14000, Caen, France.;Centre Hospitalier Universitaire de Caen Normandie, service de;gynecologie-obstetrique et de medecine de la reproduction, Avenue de la cote de;nacre, 14000, Caen, France.;Electronic address: guenole_fabian@yahoo.fr. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38959577/ |
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