Antidiabetic Drugs for the Risk of Alzheimer Disease in Patients With Type 2 DM Using FAERS.
|アブストラクト||Alzheimer disease (AD) may develop after the onset of type 2 diabetes mellitus (T2DM), and the risk of AD may depend on the antidiabetic drug administered. We compared the risk of AD among 66 085 patients (>/= 65 years) with T2DM (1250 having concomitant AD) who had been administered antidiabetic drug monotherapy for T2DM who had voluntarily reported themselves in the Food and Drug Administration Adverse Event Reporting System. The risk of AD from the use of different antidiabetic drug monotherapies compared to that of metformin monotherapy was assessed by logistic regression. Rosiglitazone (adjusted reporting odds ratio [aROR] = 0.11; 95% confidence interval [CI]: 0.07-0.17; P < .001), exenatide (aROR = 0.22; 95% CI: 0.11-0.37; P < .001), liraglutide (aROR = 0.36; 95% CI: 0.19-0.62; P < .001), dulaglutide (aROR = 0.39; 95% CI: 0.17-0.77; P = .014), and sitagliptin (aROR = 0.75; 95% CI: 0.60-0.93; P = .011) were found to have a significantly lower associated risk of AD than that of metformin. Therefore, the administration of glucagon-like peptide 1 receptor agonists and rosiglitazone may reduce the risk of AD in patients with T2DM.|
|ジャーナル名||American journal of Alzheimer's disease and other dementias|
|投稿者||Akimoto, Hayato; Negishi, Akio; Oshima, Shinji; Wakiyama, Haruna; Okita, Mitsuyoshi; Horii, Norimitsu; Inoue, Naoko; Ohshima, Shigeru; Kobayashi, Daisuke|
|組織名||Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical;Pharmaceutics and Informatics, Josai University, Sakado, Saitama, Japan.;Josai University Pharmacy, Iruma-gun, Saitama, Japan.;Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy;Management, Josai University, Sakado, Saitama, Japan.|