| アブストラクト | AIMS: Antihypertensive drugs have been implicated in coronavirus disease 2019 (COVID-19) susceptibility and severity, but estimated associations may be susceptible to bias. We aimed to evaluate antihypertensive medications and COVID-19 diagnosis and mortality, accounting for healthcare-seeking behaviour. METHODS: A population-based case-control study was conducted including 16 866 COVID-19 cases and 70 137 matched controls from the UK Clinical Practice Research Datalink. We evaluated all-cause mortality among COVID-19 cases. Exposures were angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), beta-blockers (B), calcium-channel blockers (C), thiazide diuretics (D) and other antihypertensive drugs (O). Analyses were adjusted for covariates and consultation frequency. RESULTS: ACEIs were associated with lower odds of COVID-19 diagnosis (adjusted odds ratio [AOR] 0.82, 95% confidence interval [CI] 0.77-0.88) as were ARBs (AOR 0.87, 95% CI 0.80-0.95) with little attenuation from adjustment for consultation frequency. C and D were also associated with lower odds of COVID-19 diagnosis. Increased odds of COVID-19 for B (AOR 1.19, 95% CI 1.12-1.26) were attenuated after adjustment for consultation frequency (AOR 1.01, 95% CI 0.95-1.08). Patients treated with ACEIs or ARBs had similar odds of mortality (AOR 1.00, 95% CI 0.83-1.20) to patients treated with classes B, C, D or O or patients receiving no antihypertensive therapy (AOR 0.99, 95% CI 0.83-1.18). CONCLUSIONS: There was no evidence that antihypertensive therapy is associated with increased risk of COVID-19 diagnosis or mortality; most classes of antihypertensive therapy showed negative associations with COVID-19 diagnosis. |
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| 投稿日 | 2021/4/29 |
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| 投稿者 | Rezel-Potts, Emma; Douiri, Abdel; Chowienczyk, Phil J; Gulliford, Martin C |
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| ジャーナル名 | British journal of clinical pharmacology |
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| 組織名 | King's College London, School of Population Health and Environmental Sciences,;London, UK.;National Institute for Health Research Biomedical Research Centre, Guy's and St;Thomas' NHS Foundation Trust and King's College London, London, UK.;National Institute for Health Research Applied Research Collaboration South;London, Guy's and St Thomas' NHS Foundation Trust and King's College London,;King's College London, British Heart Foundation Centre, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33908074/ |
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