OBJECTIVE: To measure the paediatric user and prescription prevalence in inpatient and ambulatory settings in South Korea, Hong Kong, Taiwan, Japan and Australia by age and gender. A further objective was to list the most commonly used drugs per drug class, per country.
DESIGN AND SETTING: Hospital inpatient and insurance paediatric healthcare data from the following databases were used to conduct this descriptive drug utilisation study: (i) the South Korean Ajou University School of Medicine database; (ii) the Hong Kong Clinical Data Analysis and Reporting System; (iii) the Japan Medical Data Center; (iv) Taiwan's National Health Insurance Research Database and (v) the Australian Pharmaceutical Benefits Scheme. Country-specific data were transformed into the Observational Medical Outcomes Partnership Common Data Model.
PATIENTS: Children (</=18 years) with at least 1 day of observation in any of the respective databases from January 2009 until December 2013 were included.
MAIN OUTCOME MEASURES: For each drug class, we assessed the per-protocol overall user and prescription prevalence rates (per 1000 persons) per country and setting.
RESULTS: Our study population comprised 1 574 524 children (52.9% male). The highest proportion of dispensings was recorded in the youngest age category (<2 years) for inpatients (45.1%) with a relatively high user prevalence of analgesics and antibiotics. Adrenergics, antihistamines, mucolytics and corticosteroids were used in 10%-15% of patients. For ambulatory patients, the highest proportion of dispensings was recorded in the middle age category (2-11 years, 67.1%) with antibiotics the most dispensed drug overall.
CONCLUSIONS: Country-specific paediatric drug utilisation patterns were described, ranked and compared between four East Asian countries and Australia. The widespread use of mucolytics in East Asia warrants further investigation.
|投稿者||Brauer, Ruth; Wong, Ian Chi Kei; Man, Kenneth Kc; Pratt, Nicole L; Park, Rae Woong; Cho, Soo-Yeon; Li, Yu-Chuan Jack; Iqbal, Usman; Nguyen, Phung-Anh Alex; Schuemie, Martijn|
|組織名||Research Department of Practice and Policy, School of Pharmacy, University;College London, London, UK.;College London, London, UK firstname.lastname@example.org.;Centre for Safe Medication Practice and Research, Department of Pharmacology and;Pharmacy, University of Hong Kong, Hong Kong, Hong Kong.;Quality Use of Medicines and Pharmacy Research Centre, University of South;Australia, Adelaide, South Australia, Australia.;Department of Biomedical Informatics, Ajou University School of Medicine, Suwon,;Republic of Korea.;Graduate Institute of Biomedical Informatics, College of Medical Science and;Technology, Taiwan Medical University, Taipei, Taiwan.;The International Center for Health Information Technology (ICHIT), Taipei;Medical University, Taipei, Taiwan.;Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan.;International Medical Informatics Association (IMIA), Geneva, Switzerland.;Masters & PhD Program in Global Health Department, College of Public Health,;Taipei Medical University, Taipei, Taiwan.;Department of Public Health and Community Medicine, Shaikh Khalifa Bin Zayed;Al-Nahyan Medical College, Shaikh Zayed Medical Complex, Lahore, Pakistan.;Epidemiology Analytics, Janssen Research and Development, Titusville, New Jersey,;USA.;Department of Biostatistics, University of California, Los Angeles, California,|