| アブストラクト | BACKGROUND: Claims data analyses are useful in clinical research. However, evidence on the validity of claims-based algorithms for identifying childbirth remains limited, particularly in settings where mother-child linkage is unavailable. Therefore, we aimed to develop and validate algorithms to identify childbirth from a claims database. METHODS: The DeSC database, including claims data for approximately 13 million people, was accessed. Eighteen algorithms were designed using combinations of diagnosis-related codes with/without a suspected flag regarding childbirth ([A+susp]/[A]), medical procedure codes [B], and medication codes [C]. We used the parent-child identifier (ID) in the DeSC database as the gold standard, which is assigned based on family relationship information recorded in the insurer-managed registry of insured persons. Parent-child ID links children to an insured parent within the same insurance unit, enabling mother-child linkage. The gold standard for the month and year of childbirth was defined as the child's month and year of birth among women aged 15-49 years linked by parent-child IDs during the observation period. We calculated sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Kappa Index, and Youden Index for each algorithm. To validate algorithms for estimating second childbirth during the observation period, which would become useful in defining childbirth, identification of second childbirth began 2-24 months after the first, given that the average age difference was two years. RESULTS: A total of 854,626 women were included in this study, of whom 37,934 were aged 15-49 years at the time of parent-child ID assignment and classified as experiencing childbirth during the observation period. The algorithm with the highest value was "[A+susp] or [B] or [C]" (sensitivity: 66.9%, specificity: 98.9%, PPV: 73.7%, NPV: 98.5%, Kappa Index: 0.69, and Youden Index: 0.66). With respect to second childbirth, algorithm "[A+susp] or [B] or [C]" showed that the 11-month difference had the highest Youden Index at 0.57. CONCLUSION: We developed algorithms based on claims data and established an optimal algorithm for estimating childbirth. This validated algorithm can be used for accurate estimation of childbirth to clarify pregnancy- and childbirth-related diseases in future claims database studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-026-08797-9. |
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| ジャーナル名 | BMC pregnancy and childbirth |
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| Pubmed追加日 | 2026/2/12 |
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| 投稿者 | Koizumi, Miyuki; Nakajima, Hiroki; Nishioka, Yuichi; Morita, Emiri; Myojin, Tomoya; Noda, Tatsuya; Imamura, Tomoaki; Takahashi, Yutaka |
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| 組織名 | Department of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-;cho, Kashihara, Nara, 634-8522, Japan.;cho, Kashihara, Nara, 634-8522, Japan. Hiroki.nakajima@naramed-u.ac.jp.;cho, Kashihara, Nara, 634-8522, Japan. y_n@naramed-u.ac.jp.;Department of Public Health, Health Management and Policy, Nara Medical;University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan. y_n@naramed-u.ac.jp.;University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.;Department of Community Health and Preventive Medicine, Hamamatsu University;School of Medicine, Shizuoka, Japan.;Department of Hygiene and Public Health, Kansai Medical University, Osaka, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41673821/ |
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