| アブストラクト | BACKGROUND: Gender differences were reported in Parkinson's disease as well as in drug effects in general. OBJECTIVE: The study was performed to investigate putative gender differences in levodopa-related adverse drug reactions (ADRs). METHODS: Using Vigibase(R), the global pharmacovigilance database, all ADRs reports with levodopa between 01/01/2000 and 31/12/2024 in adults were included. The main levodopa (motor and non-motor) ADRs were compared between women and men. Results are presented as reporting odds ratios (ROR) with their 95% confidence interval. RESULTS: Among 2887 ADRs with levodopa, the reporting risk in women was significantly higher for dyskinesia (ROR=1.31 [1.00-1.71]), dystonia (1.41 [1.03-1.93]), nausea-vomiting (2.08 [1.45-2.99]), and significantly lower for hypersexuality (0.10 [0.02-0.42]), dopamine dysregulation syndrome (0.32 [0.14-0.73]) pathological gambling (0.33 [0.14-0.76]) and all ADRs in general (0.48 [0.45-0.52]), with no difference for other ADRs. CONCLUSION: This study shows gender-related differences for not only motor (dyskinesia, dystonia) but also non-motor levodopa ADRs. |
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| ジャーナル名 | Therapie |
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| Pubmed追加日 | 2025/12/11 |
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| 投稿者 | Montastruc, Jean-Louis |
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| 組織名 | Service de Pharmacologie Medicale et Clinique, Centre Midi-Pyrenees de;PharmacoVigilance, de Pharmacoepidemiologie et d'informations sur le Medicament,;Faculte de Medecine, Centre Hospitalier Universitaire de Toulouse, 37, allees;Jules-Guesde, 31000 Toulouse, France. Electronic address: montasj33@gmail.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41372028/ |
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