| アブストラクト | OBJECTIVE: Identify trends in adverse drug reactions (ADRs) reported to the U.S. Food and Drug Administration's Adverse Event Reporting System in three subpopulations of older adults (ages 55-64, 65-74, 75+) receiving psychotropic medications. METHODS: Almost 12 years of ADR reports were compiled for adults over 55 years of age receiving psychotropic medications with known side effect profiles. A comparison of the frequency of ADRs reported, odds ratios (ORs), and 95% confidence intervals (CIs) between subpopulations to the whole population of patients aged 55+ was conducted. RESULTS: ADRs reported in three subpopulations of older adults differed significantly when receiving the same psychotropic medications. For example, reports of increased blood glucose (OR, 1.8, CI, 1.4-2.2) were all significantly increased in the youngest population (55-64). CONCLUSION: Current classification of age greater than 65 years when evaluating likely ADRs in older adults using psychotropic medications may be inadequate and require further assessment by subpopulations of older adults. |
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| ジャーナル名 | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry |
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| 投稿日 | 2018/12/7 |
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| 投稿者 | Gray, Matthew P; Dziuba, Gabrielle; Quach, Karen; Wong, Adrian; Smithburger, Pamela L; Seybert, Amy L; Kane-Gill, Sandra L |
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| 組織名 | Department of Pharmacy and Therapeutics (MPG, GD, KQ, AW, PLS, ALS, SLK),;University of Pittsburgh School of Pharmacy, Pittsburgh; Department of Pharmacy;(PLS, SLK), University of Pittsburgh Medical Center Presbyterian, Pittsburgh.;Electronic address: slk54@pitt.edu. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30503701/ |
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