| アブストラクト | OBJECTIVES: Evidence used in NICE guidance has traditionally prioritised randomised controlled trials, but increasing availability of electronic health record (EHR) data has expanded opportunities for real-world evidence. The Clinical Practice Research Datalink (CPRD) is a commonly used UK primary care EHR resource, yet the extent to which CPRD studies have informed NICE guidelines in the past decade is unclear. STUDY DESIGN: The systematic review was conducted in accordance with PRISMA guidelines. METHODS: We conducted a systematic review of CPRD studies in PubMed, MEDLINE, and Embase published between 04/16-09/25. For each eligible CPRD study, targeted searches of NICE guidelines were performed to identify explicit citations in NICE guidelines. Two reviewers screened and extracted data independently, resolving disagreements by consensus or third reviewer. Guideline information, number of guidelines over time, type of guidelines, and disease area guidelines (using British National Formulary (BNF) chapters) were described. RESULTS: 7181 records were identified. After de-duplication, 2704 unique CPRD studies were screened against NICE guidelines. Of these, 92 CPRD-based studies met inclusion criteria and were cited across 67 NICE documents. The annual number of NICE guidelines citing CPRD studies increased between 2016 and 2025; 1.5% of identified guidelines published in 2016 and 27.7% in 2025. The guideline citing the most CPRD studies was cancer related. The most common types of guidelines included clinical guidelines (49.3%) and technology appraisals (32.8%). Guidelines made up 12 different BNF categories, most frequently central nervous system related (23.9%; n = 16). CONCLUSION: Observational CPRD studies are increasingly referenced in NICE guidelines across multiple disease areas, supporting the growing role of EHR data in national guideline development. |
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| ジャーナル名 | Public health |
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| Pubmed追加日 | 2026/9/1 |
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| 投稿者 | Paul, Alwin; Nwogu, Ikenna; Hodgson, Susan; Yelland, Eleanor; Rowark, Shaun; Quint, Jennifer; Whittaker, Hannah |
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| 組織名 | School of Medicine, Imperial College London, UK.;Health Data Research UK, London, UK.;Clinical Practice Research Datalink (CPRD), Medicines and Healthcare Products;Regulatory Agency, London, UK.;National Institute for Health and Care Excellence (NICE), London, UK.;School of Public Health, Imperial College London, UK.;School of Public Health, Imperial College London, UK. Electronic address:;h.whittaker@imperial.ac.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42679782/ |
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