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Assessment of incidence and risk factors of COVID-19-associated candidemia using diagnosis procedure combination data.

• アブストラクト	BACKGROUND: Candidemia is an important coronavirus disease 2019 (COVID-19)-associated invasive fungal infection. Patients with COVID-19 may be susceptible to candidemia; however, evidence regarding its incidence, risk factors, and involvement in mortality is insufficient. OBJECTIVES: To explore the incidence of and potential risk factors for candidemia in patients with severe or critical COVID-19 and evaluate the relationship between candidemia and mortality in patients with severe or critical COVID-19. METHODS: The incidence of candidemia in patients with severe and critical COVID-19 was evaluated using administrative claims data from acute care hospitals in Japan. Multivariable regression models were used to explore potential risk factors for candidemia and their contribution to mortality in patients with severe and critical COVID-19. RESULTS: Candidemia occurred in 0.3-1.1 % of patients with severe or critical COVID-19. Renal impairment, use of steroid, blood transfusion, and use of central venous catheter were potential risk factors for candidemia in patients with severe to critical COVID-19. CONCLUSIONS: Candidemia in patients with COVID-19 was an independent risk factor for mortality. Candidemia in patients with severe to critical COVID-19 is a grave complication and may increase mortality.
  ジャーナル名	Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  Pubmed追加日	2025/3/30
  投稿者	Imoto, Waki; Ihara, Yasutaka; Bito, Tsubasa; Kawai, Ryota; Namikawa, Hiroki; Shibata, Wataru; Kaneko, Yukihiro; Shintani, Ayumi; Kakeya, Hiroshi
  組織名	Department of Infection Control Science, Osaka Metropolitan University Graduate;School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;;Department of Infectious Disease Medicine, Osaka Metropolitan University;Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan; Department of;Infection Control and Prevention, Osaka Metropolitan University Hospital, 1-5-7;Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan; Research Center for Infectious;Disease Sciences (RCIDS), Osaka Metropolitan University Graduate School of;Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan; Osaka;International Research Center for Infectious Diseases (OIRCID), Osaka;Metropolitan University, 1-2-7-601, Asahi-machi, Abeno-ku, Osaka, 545-0051,;Japan. Electronic address: wakiimoto@gmail.com.;Department of Medical Statistics, Osaka Metropolitan University Graduate School;of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan; Clinical;Research Promotion Unit, Clinical Therapeutic Trial Center, Ehime University;Hospital, Ehime, Japan, 454, Shitsukawa, Toon, Ehime, 791-0295, Japan. Electronic;address: ihara.yasutaka.gr@ehime-u.ac.jp.;of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. Electronic;address: su23654p@st.omu.ac.jp.;address: ryota.kawai@omu.ac.jp.;Department of Medical Education and General Practice, Osaka Metropolitan;University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka,;545-8585, Japan. Electronic address: hiroking.nami@gmail.com.;Japan. Electronic address: shibata.wataru@gmail.com.;Research Center for Infectious Disease Sciences (RCIDS), Osaka Metropolitan;545-8585, Japan; Osaka International Research Center for Infectious Diseases;(OIRCID), Osaka Metropolitan University, 1-2-7-601, Asahi-machi, Abeno-ku, Osaka,;545-0051, Japan; Department of Bacteriology, Osaka Metropolitan University;Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585,;Japan. Electronic address: ykaneko@omu.ac.jp.;address: ayumi.shintani@omu.ac.jp.;Japan. Electronic address: kakeya@omu.ac.jp.
  Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/40157573/

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