| アブストラクト | OBJECTIVE: To study whether subsequent pregnancy rate is reduced after appendicectomy. DESIGN: A cohort study was carried out in the General Practice Research Database, a United Kingdom primary care database. SETTING: University hospital. PATIENT(S): Female patients who underwent appendicectomy between 1986 and 2009 and appropriate comparators were followed until first pregnancy. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The association between appendicectomy and subsequent pregnancy was determined by Cox regression models. RESULT(S): The analyses included 76,426 appendicectomy patients, with 152,852 comparators from the database. There were 30,030 pregnancies (39.3%) in the appendicectomy cohort and 43,321 (28.3%) in the comparator cohort during a mean (SD) follow-up of 10.5 (6.6) years. Adjusted hazard ratios for subsequent birth rates were 1.54 (95% confidence interval, 1.52-1.56). CONCLUSION(S): Appendicectomy was associated with increased subsequent pregnancy rate in this study. This suggests that a history of appendicectomy is not associated with impaired fertility. |
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| ジャーナル名 | Fertility and sterility |
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| Pubmed追加日 | 2012/6/12 |
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| 投稿者 | Wei, Li; MacDonald, Thomas; Shimi, Sami |
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| 組織名 | Medicines Monitoring Unit, Division of Medical Sciences, School of Medicine,;Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/22683011/ |
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