| アブストラクト | BACKGROUND/AIMS: Cross-sectional studies showed an association between obesity and liver disorders. Information on incidence rates from epidemiological studies is scarce. METHODS: To explore the association between body mass index (BMI) and incident liver disorders, we conducted a follow-up study with a nested case-control analysis using the UK-based General Practice Research Database. The study population encompassed normal weight (BMI <25 kg/m(2)), pre-obese (BMI 25-29.9 kg/m(2)) or obese (BMI > or =30 kg/m(2)) subjects aged 20-79 years, matched on age, sex and general practice attended. RESULTS: Within the study population of 207,630 subjects, we identified 2718 cases of newly diagnosed liver disorder, of whom 1524 (56.1%) had known predisposing conditions. The incidence rates were 2.48 (95% CI 2.31-2.66)/1000 person-years (py) in normal weight, 2.91 (95% CI 2.72-3.11)/1000 py in pre-obese, and 3.83 (95% CI 3.62-4.07)/1000 py in obese subjects. In the nested case-control analysis, the adjusted odds ratio (OR) for obese, as compared to normal weight subjects, was 1.2 (95% CI 1.1-1.4). The OR for idiopathic cases (without known risk factors for liver disorders) was 1.3 (95% CI 1.1-1.6). CONCLUSIONS: The study indicates that obesity is associated with a modest increase in the incidence of newly diagnosed liver disorder. |
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| ジャーナル名 | Journal of hepatology |
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| Pubmed追加日 | 2002/11/26 |
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| 投稿者 | Meier, Christoph R; Krahenbuhl, Stephan; Schlienger, Raymond G; Jick, Hershel |
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| 組織名 | Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and;Toxicology, Department of Internal Medicine, University Hospital Basel,;Petersgraben 4, 4031 Basel, Switzerland. christoph.meier@unibas.ch |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/12445413/ |
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