| アブストラクト | BACKGROUND: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic, debilitating infection that predominantly affects patients with a low body mass index (BMI) and leads to progressive destruction of lung parenchyma. Although pneumonia is a common cause of death among patients with NTM-PD, information on its prognosis is scarce. We evaluated the association between BMI and outcomes in patients with NTM-PD who were hospitalized for community-acquired pneumonia (CAP). METHODS: Using the Japanese Diagnosis Procedure Combination database, we identified patients with NTM-PD hospitalized for CAP between April 1, 2012, and March 31, 2020, prior to the coronavirus disease 2019 epidemic in Japan. We evaluated in-hospital mortality as the primary outcome, and length of hospital stay and readmission due to CAP within 1 year as secondary outcomes. Restricted cubic spline regression models were used to evaluate the impact of BMI as a continuous variable on the study outcomes, adjusting for potential confounders. RESULTS: We included 13,302 patients (median age: 79 years [interquartile range IQR 72-85]; women: 63.7%; median BMI: 17.6 kg/m(2) [IQR 15.6-19.9]). The median hospital stay was 14 d (IQR 9-25), and in-hospital mortality was 10.9%. In the restricted cubic spline model, being underweight (< 18.5 kg/m(2)) was associated with a sharp increase in both in-hospital mortality and length of hospital stay. In the overweight group (25-30 kg/m(2)), high BMI was not associated with adverse outcomes. Being underweight was also associated with a modest increase in readmission because of CAP within 1 year. CONCLUSIONS: These findings indicate that assessing BMI may play a critical role in stratifying risk and optimizing management of CAP in patients with NTM-PD. |
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| ジャーナル名 | BMC infectious diseases |
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| Pubmed追加日 | 2025/8/27 |
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| 投稿者 | Tanaka, Goh; Aso, Shotaro; Jo, Taisuke; Urushiyama, Hirokazu; Yokoyama, Akira; Tamiya, Hiroyuki; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo |
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| 組織名 | Department of Internal Medicine IV, Teikyo University Mizonokuchi Hospital,;5-1-1, Futago, Takatsu-Ku, Kawasaki, Kanagawa, 213-8507, Japan.;goh.tanaka@teikyo-u.ac.jp.;Department of Respiratory Medicine, The University of Tokyo, Tokyo, Japan.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.;Department of Health Policy and Informatics, Institute of Science Tokyo Graduate;School, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40855275/ |
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