| アブストラクト | BACKGROUND: Constipation often coexists with heart failure (HF) and can cause increased blood pressure variability, which may increase the risk of repeated HF admissions. However, large-scale contemporary data regarding the prognostic effect of constipation in patients with HF are lacking. METHODS AND RESULTS: We retrospectively identified 556,792 patients admitted for HF for the first time and discharged alive in the fiscal years 2016-2021 using the Japanese Diagnosis Procedure Combination database. Constipation was defined as continued use of laxatives after discharge. We examined the association between constipation and 1-year HF readmission. The prevalence of constipation was 22.0% (n=122,670), which remained stable over the 6 years. Patients with constipation were older (82.7+/-10.1 vs. 79.3+/-12.8 years), more often female (53.5% vs. 48.0%), and received medications for HF more frequently at discharge compared with those without constipation. In the multivariable Cox proportional hazards model, constipation was significantly associated with a higher incidence of 1-year HF readmission (24.0% vs. 18.6%; adjusted hazard ratio [HR] 1.08; 95% confidence interval [CI] 1.06-1.10). This result was consistent with the result from the Fine-Gray model accounting for competing risk of death (subdistribution HR 1.08; 95% CI 1.06-1.09). CONCLUSIONS: Constipation was associated with a higher risk of HF readmission after the first episode of HF hospitalization. Given the detrimental effect of constipation, further efforts are warranted to decrease constipation-related risk in patients with HF. |
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| ジャーナル名 | Circulation reports |
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| Pubmed追加日 | 2024/11/13 |
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| 投稿者 | Isogai, Toshiaki; Morita, Kojiro; Okada, Akira; Michihata, Nobuaki; Matsui, Hiroki; Miyawaki, Atsushi; Yasunaga, Hideo |
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| 組織名 | Department of Cardiology, Tokyo Metropolitan Tama Medical Center Tokyo Japan.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo Tokyo Japan.;Department of Nursing Administration and Advanced Clinical Nursing, Graduate;School of Medicine, The University of Tokyo Tokyo Japan.;Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate;Cancer Prevention Center, Chiba Cancer Center Research Institute Chiba Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo Tokyo Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39525299/ |
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