| アブストラクト | PURPOSE: It has been reported recently that immune reactions are involved in the pathogenesis of certain types of adverse drug reactions (ADRs). We aimed to determine the associations between infections and drug-induced interstitial lung disease (DILD), rhabdomyolysis, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), or drug-induced liver injury (DILI) using a spontaneous adverse drug event reporting database in Japan. METHODS: The reported cases were classified into three categories (anti-infectious drug group, concomitant infection group, and non-infection group) based on the presence of anti-infectious drugs (either as primary suspected drug or concomitant drug) and infectious disease. We assessed the association between four severe ADRs and the presence and seriousness of infection using logistic regression analysis. RESULTS: We identified 177,649 cases reported in the study period (2009-2013). Logistic regression analysis showed significant positive associations between infection status and onset of SJS/TEN or DILI (SJS/TEN: anti-infectious drug group: anti-infectious drug group: CONCLUSIONS: This study suggested that infection plays an important role in the development of SJS/TEN and DILI. For the patients with infection and/ or anti-infectious drugs, careful monitoring for severe ADRs, especially SJS/TEN, might be needed. |
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| 投稿日 | 2017/8/24 |
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| 投稿者 | Imatoh, Takuya; Sai, Kimie; Fukazawa, Chisato; Hinomura, Yasushi; Nakamura, Ryosuke; Okamoto-Uchida, Yoshimi; Segawa, Katsunori; Saito, Yoshiro |
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| ジャーナル名 | European journal of clinical pharmacology |
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| 組織名 | Division of Medicinal Safety Science, National Institute of Health Sciences,;Kamiyoga 1-18-1, Setagaya-ku, Tokyo, 158-8501, Japan. imatoh@nihs.go.jp.;Kamiyoga 1-18-1, Setagaya-ku, Tokyo, 158-8501, Japan.;Japan Pharmaceutical Information Center, Shibuya 2-12-15, Shibuya-ku, Tokyo,;150-0002, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28831528/ |
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