Association between myocarditis and antipsychotics other than clozapine: a systematic literature review and a pharmacovigilance study using VigiBase.
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アブストラクト INTRODUCTION:Pharmacovigilance studies have definitely established that clozapine can cause myocarditis. Two published reviews suggested that on rare occasions other antipsychotics may induce myocarditis.AREAS COVERED:This review explored myocarditis associated with antipsychotics other than clozapine by conducting a systematic search of the literature and critically analyzing the current data in VigiBase compared to the data on clozapine-associated myocarditis. VigiBase is the World Health Organization's global pharmacovigilance database that uses a statistical signal for associations with a logarithmic measure of disproportionality called the information component (IC).EXPERT OPINION:For quetiapine, VigiBase provided 106 reports of myocarditis and a significant statistical signal (IC = 1.8; IC025 = 1.5) which was confounded by 48% (51/106) with clozapine co-prescription. Combining the literature and VigiBase cases provided five probable myocarditis cases during quetiapine monotherapy (4 after overdose or rapid titration). For olanzapine, VigiBase provided 107 reports of myocarditis and a significant statistical signal (IC = 2.1; IC025 = 1.8) probably explained by 77% (82/107) using clozapine co-prescription. Combining the literature and VigiBase cases provided one probable myocarditis case during olanzapine monotherapy. Combining the literature and VigiBase provided another three probable cases during therapy with other antipsychotics during overdose or titration with a high dose.ジャーナル名 Expert review of clinical pharmacology 投稿日 2022/1/23 投稿者 De Las Cuevas, Carlos; Sanz, Emilio J; Rohde, Christopher; de Leon, Jose 組織名 Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine,;University of La Laguna, Canary Islands, Spain.;Instituto Universitario de Neurociencia (IUNE), Universidad de La Laguna, San;Cristobal de La Laguna, Spain.;Department of Physical Medicine and Pharmacology, School of Medicine, Universidad;de La Laguna, Canary Islands, Spain.;Hospital Universitario de Canarias, Tenerife, Spain.;Department of Affective Disorders, Aarhus University Hospital - Psychiatry,;Aarhus, Denmark.;Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.;Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.;Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol;Hospital, University of the Basque Country, Vitoria, Spain. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/35062840/ -
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