| アブストラクト | Nafamostat mesylate may be effective against coronavirus disease 2019 (COVID-19). However, it is not known whether its use is associated with reduced in-hospital mortality in clinical practice. We conducted a retrospective observational study to evaluate the effect of nafamostat mesylate in patients with COVID-19 using the Medical Data Vision Co. Ltd. hospital-based database in Japan. We compared patients with COVID-19 who were (n = 121) and were not (n = 15,738) administered nafamostat mesylate within 2 days of admission between January and December 2020. We conducted a 1:4 propensity score matching with multiple imputations for smoking status and body mass index and combined the 20 imputed propensity score-matched datasets to obtain the adjusted odds ratio for in-hospital mortality. Crude in-hospital mortality was 13.2% (16/121) and 5.0% (790/15,738), respectively. In the propensity score-matched analysis with multiple imputations, the adjusted odds ratio (use vs. no use of nafamostat mesylate) for in-hospital mortality was 1.27 (95% confidence interval: 0.61-2.64; p = 0.52). Sensitivity analyses showed similar results. The results of this retrospective observational study did not support an association between nafamostat mesylate and improved in-hospital outcomes in patients with COVID-19, although further studies with larger sample sizes are warranted to assess the generalizability of our findings. |
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| ジャーナル名 | Journal of clinical medicine |
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| 投稿日 | 2022/1/12 |
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| 投稿者 | Inokuchi, Ryota; Kuno, Toshiki; Komiyama, Jun; Uda, Kazuaki; Miyamoto, Yoshihisa; Taniguchi, Yuta; Abe, Toshikazu; Ishimaru, Miho; Adomi, Motohiko; Tamiya, Nanako; Iwagami, Masao |
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| 組織名 | Department of Health Services Research, Faculty of Medicine, University of;Tsukuba, Tsukuba 305-8575, Japan.;Montefiore Medical Center, Division of Cardiology, Albert Einstein College of;Medicine, New York, NY 10461, USA.;Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba;305-8575, Japan.;Health Services Research and Development Center, University of Tsukuba, Tsukuba;National Cancer Center, Institute for Cancer Control, Tokyo 104-0045, Japan.;Department of Emergency and Critical Care Medicine, Tsukuba Memorial Hospital,;Tsukuba 305-8575, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35011857/ |
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