| アブストラクト | BACKGROUND: Black men have higher prostate-specific antigen (PSA) levels and higher prostate cancer incidence and mortality than White men, while Asian men tend to have lower prostate cancer incidence and mortality than White men. Much of the evidence comes from the USA, and information from UK populations is limited. METHODS: This retrospective cohort study used data on patients registered at general practices in England contributing to the Clinical Practice Research Datalink (CPRD) Aurum dataset. Those eligible were men aged 40 and over with a record of ethnicity and a PSA test result recorded between 2010 and 2017 with no prior cancer diagnosis. The aim was to assess the incidence of prostate cancer following a raised PSA test result in men from different ethnic groups. Additionally, incidence of advanced prostate cancer was investigated. Cancer incidence was estimated from multi-level logistic regression models adjusting for potential confounding factors. RESULTS: 730,515 men with a PSA test were included (88.9% White). Black men and men with mixed ethnicity had higher PSA values, particularly for those aged above 60 years. In the year following a raised PSA result (using age-specific thresholds), Black men had the highest prostate cancer incidence at 24.7% (95% CI 23.3%, 26.2%); Asian men had the lowest at 13.4% (12.2%, 14.7%); incidence for White men was 19.8% (19.4%, 20.2%). The peak incidence of prostate cancer for all groups was in men aged 70-79. Incidence of prostate cancer diagnosed at an advanced stage was similar between Black and White men. CONCLUSIONS: More prostate cancer was diagnosed in Black men with a raised PSA result, but rates of advanced prostate cancer were not higher in this group. In this large primary care-based cohort, the incidence of prostate cancer in men with elevated PSA levels increases with increasing age, even when using age-adjusted thresholds, with Black men significantly more likely to be diagnosed compared to White or Asian men. The incidence of advanced stage prostate cancer at diagnosis was similar for Black and White men with a raised PSA result, but lower for Asian men. |
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| ジャーナル名 | BMC medicine |
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| Pubmed追加日 | 2024/3/1 |
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| 投稿者 | Down, Liz; Barlow, Melissa; Bailey, Sarah E R; Mounce, Luke T A; Merriel, Samuel W D; Watson, Jessica; Martins, Tanimola |
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| 組織名 | Department of Health and Community Sciences, University of Exeter, St Lukes;Campus, Heavitree Road, Exeter, EX1 2LU, UK. e.a.down@exeter.ac.uk.;Campus, Heavitree Road, Exeter, EX1 2LU, UK.;Centre for Primary Care & Health Services Research, University of Manchester,;Oxford Road, Manchester, M13 9PL, UK.;Centre for Academic Primary Care (CAPC), Population Health Sciences, Bristol;Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol,;BS8 2PS, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38424555/ |
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