| アブストラクト | PURPOSE: Previous studies have reported contradictory findings about the possible association between SARS-CoV-2 and diabetes. We therefore conducted a cohort study to determine whether there is any association between SARS-CoV-2 infection and (i) new onset Type 1 diabetes and (ii) new onset Type 2 diabetes. METHODS: We conducted a population-based cohort study on data from 01/01/2021 to 30/06/2022 using the UK Clinical Practice Research Datalink (CPRD) GOLD. In this database, the exposure cohort (Covid) was matched to the comparator cohort (No Covid), 1:1 with months as "enrolment" windows during 2021, without replacement. Large Scale Propensity Score matching was conducted using Lasso regression for variable selection. Then Poisson regression was used to examine the relationship between COVID-19 exposure and incident Type 1/Type 2 diabetes. A sensitivity analysis was performed by matching Covid cases with Negative tests. RESULTS: 161,870 COVID-19 patients were matched to 161,870 non-Covid controls; separately, 139,419 COVID-19 patients were matched to 139,419 test-negative participants. For Type 1 diabetes, the Poisson regression analysis gave an overall risk ratio of 1.27 (0.81-1.82); and a RR of 1.13 (0.66-1.84) when matching Covid with Negative tests. For Type 2 diabetes, we obtained an overall risk ratio of 1.10 (0.98-1.23); and a RR of 1.08 (0.96-1.20) when matching Covid with Negative tests. CONCLUSIONS: We do not find evidence of an association between SARS-CoV-2 infection and new onset of Type 1 or Type 2 diabetes. However, uncertainty remains due to the small number of events, especially in the case of Type 1 diabetes. CLINICAL TRIAL NUMBER: Not applicable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-026-02002-6. |
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| ジャーナル名 | Journal of diabetes and metabolic disorders |
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| Pubmed追加日 | 2026/7/10 |
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| 投稿者 | Spivakovsky, P; Barclay, N L; Burn, E; Man, W Y; Delmestri, A; Jodicke, A M; Prieto-Alhambra, Daniel; Catala, M |
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| 組織名 | Botnar Research Centre, Centre for Statistics in Medicine (CSM), NDORMS,;University of Oxford, Old Rd, Headington, Oxford, OX3 7LD UK. ROR:;https://ror.org/052gg0110. GRID: grid.4991.5. ISNI: 0000 0004 1936 8948;Dept. of Clinical Neurosciences, University of Oxford, Oxford, UK. ROR:;Dept. of Medical Informatics, Erasmus University Medical Centre, Rotterdam,;Netherlands. ROR: https://ror.org/018906e22. GRID: grid.5645.2. ISNI: 0000 0004;0459 992X |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42428026/ |
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