Association Between Steroid Use and Nephropathy in Patients Who Were Administered a Proton Pump Inhibitor: Analysis of the Japanese Adverse Event Report Database.
|アブストラクト||This study used the Japanese Adverse Drug Event Report database to investigate whether steroid use decreases the risk of nephropathy in patients who were administered a proton pump inhibitor (PPI). Disproportionality of kidney injury was observed between patients who did and those who did not use steroids while taking lansoprazole (reporting odds ratio, 0.78; 95% confidence interval [CI], 0.65-0.93; P = .002) or rabeprazole (reporting odds ratio, 0.69; 95%CI, 0.53-0.89; P = .005). Multiple logistic regression analysis revealed a significantly negative association of kidney injury with steroid use (odds ratio [OR], 0.85; 95%CI, 0.75-0.96; P = .011) and a significantly positive association with the presence of chronic kidney disease (OR, 1.66; 95%CI, 1.44-1.90; P < .001), the presence of comorbidities that relate to nephropathy (OR, 1.43; 95%CI, 1.29-1.59; P < .001), male sex (OR, 1.25; 95%CI, 1.13-1.39; P < .001), and age >/=80 years (OR, 1.21; 95%CI, 1.07-1.37; P = .002). These findings suggest that steroid use may decrease the risk of proton pump inhibitor-induced nephropathy.|
|投稿者||Mitsuboshi, Satoru; Kaseda, Ryohei; Narita, Ichiei|
|ジャーナル名||Journal of clinical pharmacology|
|組織名||Department of Pharmacy, Kaetsu Hospital, Niigata, Japan.;Division of Clinical Nephrology and Rheumatology, Niigata University Graduate;School of Medical and Dental Sciences, Niigata, Japan.|