| アブストラクト | OBJECTIVES: To investigate the association between the number of teeth and the new onset of pre-diabetes. DESIGN: Retrospective cohort study. SETTING: The National Database of Health Insurance Claims and Specific Health Checkups of Japan, which holds information from both the yearly health check-up programme known as the 'Specific Health Checkup' and health insurance claims data. PARTICIPANTS: 1 098 371 normoglycaemic subjects who participated in the Specific Health Checkup programme every year from fiscal year (FY) 2015 to FY 2018 and had dental insurance claims data with a diagnosis of periodontal disease during FY 2016. OUTCOME MEASURES: Incidence of pre-diabetes or diabetes observed at the Specific Health Checkup during FY 2018. RESULTS: Among the participants, 1 77 908 subjects developed pre-diabetes, and 579 developed diabetes at the check-up during the subsequent follow-up year. Compared with the subjects with 26-28 teeth, those with 20-25, 15-19 or 1-14 teeth were associated with an increased likelihood of developing pre-diabetes or diabetes onset with adjusted ORs of 1.03 (95% CI: 1.02 to 1.05), 1.06 (1.03 to 1.09) and 1.07 (1.04 to 1.11), respectively. No clear modifications were observed for age, sex, body mass index or current smoking. CONCLUSIONS: Having fewer teeth was associated with a higher incidence of pre-diabetes. Due to the limitations of this study, however, causality remains undetermined. |
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| ジャーナル名 | BMJ open |
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| 投稿日 | 2023/11/21 |
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| 投稿者 | Hasegawa, Kohei; Sakurai, Akinari; Mizuki, Masaru; Kurita, Hiroshi; Tsukahara, Teruomi; Nomiyama, Tetsuo |
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| 組織名 | Department of Preventive Medicine and Public Health, Shinshu University School of;Medicine, Matsumoto, Nagano, Japan koheih@shinshu-u.ac.jp.;Department of Dentistry and Oral Surgery, Shinshu University School of Medicine,;Matsumoto, Nagano, Japan.;Center for Perinatal, Pediatric, and Environmental Epidemiology, Shinshu;University School of Medicine, Matsumoto, Nagano, Japan.;Medicine, Matsumoto, Nagano, Japan.;Department of Occupational Medicine, Shinshu University School of Medicine, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37984959/ |
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