| アブストラクト | BACKGROUND: There is disparity between the sexes in cardiovascular diseases including heart failure (HF). This study aimed to investigate the effect of periodontal disease (PD) on plasma B-type natriuretic peptide (BNP) concentration across sex, age, and menopausal status, as well as the interaction effect of MT and diabetes mellitus (DM) on BNP. METHODS: This large-scale prospective cohort study enrolled 7,539 individuals with no myocardial infarctions or angina pectoris at baseline from the general Japanese population. The association between baseline number of missing teeth (MT) and the longitudinal changes in BNP over 5 years (DeltaBNP) was evaluated according to sex and menopausal status. RESULTS: Among 7,539 participants, 3,190 were postmenopausal women with a mean age +/- standard deviation of 61.1 +/- 7.6 at baseline. Multivariate analysis revealed a positive association between MT and DeltaBNP among postmenopausal women even after adjusting for covariates, including traditional HF risk factors (coefficient, 0.210; 95% confidence interval [CI], 0.107 to 0.312; P <0.001), but not in men aged >50. Including an interaction term (MTxDM) in the multivariate model revealed a positive interaction between MT and DM in DeltaBNP among postmenopausal women (coefficient for interaction, 1.365; 95% CI, 0.902 to 1.827; P for interaction <0.001). CONCLUSIONS: Our study showed a positive association between MT and DeltaBNP, as well as a positive effect of the interactive association between MT and DM, among postmenopausal women. Our results suggest a sex difference of an adverse effect of PD on initial myocardial wall stress in the ventricles. |
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| 投稿日 | 2021/9/29 |
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| 投稿者 | Fukuhara, Shizuko; Asai, Keita; Fukuhara, Takehisa; Kakeno, Asumi; Yamanaka, Shigeki; Nakao, Kazumasa; Watanabe, Takuma; Takahashi, Katsu; Yamazaki, Toru; Umebachi, Chisa; Kashiwagi, Marina; Setoh, Kazuya; Kawaguchi, Takahisa; Tabara, Yasuharu; Morita, Satoshi; Nakayama, Takeo; Matsuda, Fumihiko; Nakao, Kazuwa; Bessho, Kazuhisa |
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| ジャーナル名 | Current problems in cardiology |
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| 組織名 | Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto;University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic;address: fuku810@kuhp.kyoto-u.ac.jp.;address: k.asai@kuhp.kyoto-u.ac.jp.;Fukuhara Naika Clinic for Cardiovascular and Internal Medicine, 16-27 Katsube;1-chome Moriyama-shi, Shiga 524-0041, Japan. Electronic address:;fukuhara@jungle.or.jp.;address: amipom@kuhp.kyoto-u.ac.jp.;address: yama0821@kuhp.kyoto-u.ac.jp.;address: knakao@kuhp.kyoto-u.ac.jp.;address: takuma@kuhp.kyoto-u.ac.jp.;address: takahask@kuhp.kyoto-u.ac.jp.;address: toruym@gmail.com.;address: chisa_0327@kuhp.kyoto-u.ac.jp.;address: kashiwagim@kuhp.kyoto-u.ac.jp.;Center for Genomic Medicine, Graduate School of Medicine, Kyoto University,;Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:;k.setoh@genome.med.kyoto-u.ac.jp.;tkawa@genome.med.kyoto-u.ac.jp.;tabara.yasuharu.8x@kyoto-u.ac.jp.;Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate;School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.;Electronic address: smorita@kuhp.kyoto-u.ac.jp.;Department of Health Informatics, Kyoto University School of Public Health,;Yoshida-Konoe-Cho, Sakyo-ku, Kyoto, 606-8501, Japan. Electronic address:;nakayama.takeo.4a@kyoto-u.ac.jp.;fumi@genome.med.kyoto-u.ac.jp.;Medical Innovation Center, Kyoto University Graduate School of Medicine, 53;nakao@kuhp.kyoto-u.ac.jp.;address: bes@kuhp.kyoto-u.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34582901/ |
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