| アブストラクト | A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 +/- 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates. On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, p < 0.001) and in-hospital mortality within 7 days and 30 days (0.9 vs. 2.5%, OR, 0.34, and 3.8 vs. 6.5%, OR: 0.56, both p < 0.001). In the sub-group analysis, mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and beta-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials. |
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| ジャーナル名 | Nutrients |
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| Pubmed追加日 | 2021/1/28 |
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| 投稿者 | Kusunose, Kenya; Okushi, Yuichiro; Okayama, Yoshihiro; Zheng, Robert; Abe, Miho; Nakai, Michikazu; Sumita, Yoko; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka |
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| 組織名 | Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima;770-8503, Japan.;Clinical Research Center for Developmental Therapeutics, Tokushima University;Hospital, Tokushima 770-8503, Japan.;Center for Cerebral and Cardiovascular Disease Information, National Cerebral and;Cardiovascular Center, Osaka 564-8565, Japan.;Department of Community Medicine for Cardiology, Tokushima University Graduate;School of Biomedical Sciences, Tokushima 770-8503, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33498709/ |
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