| アブストラクト | AIMS: We investigated the impact of intentional weight loss on health care resource utilization (HCRU) and costs among people with obesity. MATERIALS AND METHODS: This retrospective, observational cohort study used data from the Clinical Practice Research Datalink (CPRD) GOLD database. Adults >18 years at index date [first recorded body mass index (BMI) of 30-50 kg/m(2) between 2006 and 2015 with a further BMI record 4 years later] were assigned to an intentional weight loss cohort (-25% to -10% BMI change) or a stable weight cohort (-3% to +3%), based on their BMI change during a 4-year baseline period from index date. Evidence of intention to lose weight during the baseline period was required. Linked Hospital Episode Statistics datasets captured HCRU and costs over an 8-year follow-up period. Mixed effects models adjusted for demographics, total costs during baseline and baseline comorbidities were used. RESULTS: Baseline characteristics were similar between cohorts with weight loss (n = 8676) and stable weight (n = 44 519). Over follow-up, the weight loss cohort experienced a significantly lower mean annual increase in total costs [2.1% (95% confidence interval: 1.3-2.8)] than the stable weight cohort [4.3% (95% confidence interval: 4.0-4.6); p < .0001]. Weight loss was associated with a lower mean annual increase in multiple HCRU and cost components compared with maintaining a stable high weight. CONCLUSIONS: Our findings suggest that intentional weight loss of 10-25% is associated with lower HCRU and costs in the long term among individuals living with obesity, relative to stable weight. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| 投稿日 | 2023/9/11 |
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| 投稿者 | Bojke, Chris; Capucci, Silvia; Haase, Christiane Lundegaard; Hartvig, Niels Vaever; Sommer Matthiessen, Kasper; Morgen, Camilla S; Rendon, Adriana; Pearson-Stuttard, Jonathan |
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| 組織名 | Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.;Novo Nordisk A/S, Soborg, Denmark.;Department of Epidemiology and Biostatistics, School of Public Health, Imperial;College London, London, UK.;Health Analytics, Lane Clark & Peacock LLP, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37691253/ |
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