| アブストラクト | BACKGROUND: COVID-19 vaccines have played a crucial role in reducing the burden of the global pandemic. However, recent case reports have indicated the association of the COVID- 19 vaccines with cardiovascular events but the exact association is unclear so far. OBJECTIVE: Therefore, the objective of the current study is to find out the association of cardiovascular events with COVID-19 vaccines. METHODS: The COVID-19 Vaccine Knowledge Base (Cov19VaxKB) tool was used to query the Vaccine Adverse Event Reporting System (VAERS) database. The proportional reporting ratio [PRR (>/=2)] with associated chi-squared value (>4), and the number of cases > 0.2% of total reports, was used to assess the association of COVID-19 vaccines with cardiovascular events. RESULTS: A total of 33,754 cases of cardiovascular events associated with COVID-19 vaccines were found in the Cov19VaxKB tool. The cases were observed in different age groups (18-64, and 65 years and above) and gender. The disproportionality measures indicate a statistically significant association between cardiovascular events and COVID-19 vaccines. CONCLUSION: The current study identified a signal of various cardiovascular events with the COVID-19 vaccines. However, further causality assessment is required to confirm the association. |
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| ジャーナル名 | Current drug safety |
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| 投稿日 | 2023/11/30 |
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| 投稿者 | Amir, Mohd; Latha, S; Sharma, Ruchika; Kumar, Anoop |
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| 組織名 | Department of Clinical Research, Delhi Institute of Pharmaceutical Sciences and;Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPSRU),;New Delhi, 110017, India.;Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and;Centre for Precision Medicine and Pharmacy, Delhi Pharmaceutical Sciences and;Research University (DPSRU), New Delhi 110017, India. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38031796/ |
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