| アブストラクト | PURPOSE: We aimed to optimize antiemetic strategies by evaluating the association of co-administration of neurokinin-1 receptor antagonist (NK1-RA) administration and dexamethasone on new-onset diabetes in patients receiving chemotherapy. METHODS: This retrospective cross-sectional study was conducted using the DeSC database and included patients aged >/= 18 years with solid tumors who initiated parenteral anticancer agents and dexamethasone between April 2014 and March 2023. Patients with a history of diabetes or hematologic malignancies were excluded. The primary outcome was new-onset diabetes during the 2 months following the index month, defined by International Classification of Diseases, Tenth Revision codes or prescription data. Multivariable logistic regression assessed the association between co-administration of NK1-RA and dexamethasone and new-onset diabetes. RESULTS: Among 71,539 eligible patients, 51.1% received NK1-RAs. Co-administration of NK1-RA and dexamethasone was significantly associated with an increased risk of new-onset diabetes (adjusted odds ratio: 1.43; 95% confidence interval: 1.31-1.55; p < 0.001). Sensitivity analyses demonstrated consistent results across different evaluation periods and outcome definitions. CONCLUSION: Co-administration of NK1-RA and dexamethasone was associated with an increased risk of new-onset diabetes. These findings highlight a previously unrecognized safety signal and support the careful management of dexamethasone, as recommended by many clinical guidelines. |
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| 投稿者 | Ozawa, Yuki; Suzuki, Shinya; Koinuma, Takuma; Yokokawa, Takashi; Ichimura, Takenori; Suzuki, Kenichi; Hori, Yusuke; Imai, Shinobu |
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| 組織名 | Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of;Pharmacy and Life Sciences, Tokyo, Japan.;Department of Pharmacy, Kanagawa Prefectural Keiyukai, Keiyu Hospital, Kanagawa,;Japan.;Drug Informatics Group, Laboratory of Clinical Pharmacy, School of Pharmacy,;Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi,;Hachioji-City, Tokyo, 192-0392, Japan. ssuzuki@toyaku.ac.jp.;Hachioji-City, Tokyo, 192-0392, Japan.;Division of Pharmacoepidemiology, Showa Medical University Graduate School of;Pharmacy, Tokyo, Japan. |
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