| アブストラクト | The administration of COVID-19 vaccines has become increasingly essential to curb the pandemic. However, adverse events of acute kidney injury (AKI) emerge rapidly as the COVID-19 vaccination promotes. To investigate the intervenable risk factors of AKI, we searched the Vaccine Adverse Event Reporting System database and recorded adverse effects after COVID-19 vaccines from Dec 2020 to Jun 2021. We included 1149 AKI cases, of which 627 (54.6%) cases were reported following the Pfizer-BNT COVID-19 vaccine, and 433 (37.7%) were reported after the Moderna vaccine. A univariate analysis revealed that coexisting active illnesses (infections, uncontrolled hypertension, heart failure, etc.) have an unfavorable prognosis, with an increased risk of death (OR 2.35, 95% CI 1.70-3.25, p < 0.001). The other risk factors included older age and past disease histories. An adjusted regression analysis proved that coexisting active illnesses worsen AKI prognosis after COVID-19 vaccination, with a higher mortality risk (OR 2.19, 95% CI 1.48-3.25, p < 0.001). In subgroup analysis, we stratified different variables, and none revealed a significant effect modification on the association between coexisting active illnesses and AKI-associated death after vaccination (p-interaction >0.05). We found that coexisting active illnesses could complicate AKI after vaccines, but the potential causal relationship needed further investigation. |
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| ジャーナル名 | Vaccines |
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| 投稿日 | 2022/5/29 |
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| 投稿者 | Chen, Gang; Ren, Qidong; Zhou, Jiannan; Zhou, Yangzhong; Luo, Huiting; Wang, Yining; Li, Xiaolin; Zhao, Bin; Li, Xuemei |
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| 組織名 | Nephrology Department, Institute of Materia Medica, Peking Union Medical College;Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,;Beijing 100730, China.;School of Medicine, Tsinghua University, Beijing 100730, China.;Nephrology Department, Beijing Aerospace General Hospital, Beijing 100076, China.;Pharmacy Department, Institute of Materia Medica, Peking Union Medical College;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,;Institute of Materia Medica, Peking Union Medical College Hospital, Peking Union;Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35632462/ |
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