| アブストラクト | BACKGROUND AND PURPOSE: The roles of blood low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides in the development of post-stroke dementia remain uncertain. This study was to investigate their potential associations. METHODS: A retrospective cohort study was conducted using the Clinical Practice Research Datalink. Patients with first-ever stroke but no prior dementia were followed up for 10 years. Cox regression was used to examine the association of baseline LDL-C, HDL-C and triglycerides with post-stroke dementia. RESULTS: Amongst 63,959 stroke patients, 15,879 had complete baseline data and were included in our main analysis. 10.8% developed dementia during a median of 4.6 years of follow-up. The adjusted hazard ratio of dementia for LDL-C (per log mmol/l increase) was 1.29 (95% confidence interval [CI] 1.14-1.47), with a linear increasing trend (p trend <0.001). The counterpart for triglycerides was 0.79 (95% CI 0.69-0.89), with a linear decreasing trend (p trend <0.001). For HDL-C, there was no association with dementia (adjusted hazard ratio 0.89, 95% CI 0.74-1.08) or a linear trend (p trend = 0.22). CONCLUSIONS: Blood lipids may affect the risk of post-stroke dementia in different ways, with higher risk associated with LDL-C, lower risk associated with triglycerides, and no association with HDL-C. |
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| ジャーナル名 | European journal of neurology |
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| 投稿日 | 2021/12/18 |
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| 投稿者 | Yang, Zhirong; Edwards, Duncan; Burgess, Stephen; Brayne, Carol; Mant, Jonathan |
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| 組織名 | Primary Care Unit, Department of Public Health and Primary Care, School of;Clinical Medicine, University of Cambridge, Cambridge, UK.;Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen,;China.;MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge,;Cambridge, UK.;Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care,;School of Clinical Medicine, University of Cambridge, Cambridge, UK.;Cambridge Public Health, School of Clinical Medicine, University of Cambridge, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34918445/ |
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