| アブストラクト | Encephalopathy is the most severe complication of various common infections, including influenza and herpes, and it often results in death or severe neurological disability. The risk factors for viral encephalopathy include non-steroidal anti-inflammatory drug (NSAID) use; however, studies on NSAID-related encephalopathy are limited. In this study, we aimed to investigate the characteristics of NSAID-related encephalopathy. We investigated the incidence of NSAID-related encephalopathy using data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) and Japanese Adverse Drug Event Report (JADER) databases containing reports on spontaneous adverse effects (AEs) published by the Pharmaceuticals and Medical Devices Agency. We used these databases to detect AEs based on reported odds ratios. By separating suspicious drugs, concomitant drugs, and drug interactions involving NSAIDs, we investigated the relationship between encephalopathy pathology and AEs of NSAIDs. Significant encephalopathy signals were detected for loxoprofen and etodolac in the FAERS database and loxoprofen in the JADER database. In the JADER database, significant encephalopathy signals in loxoprofen-treated patients were detected in 70-79-year-old, >/=80-year-old, influenza viral infection, and herpes virus infection groups. Significant encephalopathy signals in patients with herpes virus infection were detected in the >/=80-year-old and loxoprofen-treated groups. Regarding the involvement of loxoprofen in the development of encephalopathy, the JADER database listed loxoprofen as a suspect drug, without indicating any concomitant drug interactions. In conclusion, our findings suggest that loxoprofen and etodolac may be associated with viral encephalopathy. Accordingly, prudence is recommended when using loxoprofen in older individuals with viral infections. |
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| ジャーナル名 | Die Pharmazie |
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| 投稿日 | 2024/6/15 |
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| 投稿者 | Kawada, K; Ishida, T; Yoshioka, T; Fukuda, H; Hayashi, T; Goda, M; Ishizawa, K |
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| 組織名 | Department of Clinical Pharmacy Practice Pedagogy, Tokushima University Graduate;School of Biomedical Sciences; Department of Clinical Pharmacology and;Therapeutics, Tokushima University Graduate School of Biomedical Sciences,;Tokushima University.;Department of Pharmacy, Kochi Medical School Hospital, Kochi.;Department of Clinical Pharmacology and Therapeutics, Tokushima University;Graduate School of Biomedical Sciences, Tokushima University; Department of;Pharmacy, Tokushima University Hospital, Tokushima.;Department of Neurosurgery, Kochi Medical School, Kochi University, Kochi.;Department of Pharmaceutical and Health Care Management, Faculty of;Pharmaceutical Sciences, Fukuoka University, Fukuoka.;Pharmacy, Tokushima University Hospital, Tokushima; Clinical Research Center for;Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38877682/ |
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