| アブストラクト | BACKGROUND: Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS: We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression. RESULTS: Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR=1.22, 95% CI=1.03-1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association. CONCLUSIONS: Our results do not support a role of antibiotic use in liver cancer development. |
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| ジャーナル名 | British journal of cancer |
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| Pubmed追加日 | 2016/05/25 |
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| 投稿者 | Yang, Baiyu; Hagberg, Katrina Wilcox; Chen, Jie; Sahasrabuddhe, Vikrant V; Graubard, Barry I; Jick, Susan; McGlynn, Katherine A |
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| 組織名 | Division of Cancer Epidemiology and Genetics, National Cancer Institute,;Bethesda, MD 20892-9774 USA.;Boston Collaborative Drug Surveillance Program and Boston University School of;Public Health, Lexington, MA, 02421 USA.;Division of Cancer Prevention, National Cancer Institute, Bethesda, MD;20892-9783, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27219020/ |
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