| アブストラクト | INTRODUCTION/AIMS: There are limited studies on the association of COVID-19 vaccination with neuralgic amyotrophy (NA). Therefore, we evaluated the association between COVID-19 vaccination and the occurrence of NA. METHODS: We explored unexpected safety signals for NA related to COVID-19 vaccination through disproportionality analysis using VigiBase, the World Health Organization's pharmacovigilance database. RESULTS: On October 15, 2021, 335 cases of NA were identified in the database. The median time to onset of NA after vaccination was around 2 weeks. A significant signal of disproportionality of NA was observed for the ChAdOx1 nCoV-19 vaccine (AstraZeneca) (information component [IC](025) = 0.33, reporting odds ratio [ROR](025) = 1.30) and two mRNA-based COVID-19 vaccines (BNT162b2 [Pfizer and BioNTech] and mRNA-1273 [Moderna]) (IC(025) = 1.74, ROR(025) = 3.82) compared with the entire database. However, when compared with influenza vaccines, we did not detect any signal of disproportionality of NA for both the ChAdOx1 nCoV-19 vaccine (IC(025) = -2.71, ROR(025) = 0.05) and mRNA-based COVID-19 vaccines (IC(025) = -1.38, ROR(025) = 0.13). DISCUSSION: A weak association was observed between NA and COVID-19 vaccines. However, the risk did not surpass that of influenza vaccines. |
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| ジャーナル名 | Muscle & nerve |
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| 投稿日 | 2022/10/11 |
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| 投稿者 | Kim, Jee-Eun; Park, Jin; Min, Young Gi; Hong, Yoon-Ho; Song, Tae-Jin |
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| 組織名 | Department of Neurology, Seoul Hospital, Ewha Woman's University College of;Medicine, Seoul, Republic of Korea.;Department of Neurology, Seoul National University Hospital, Seoul, Republic of;Korea.;Department of Neurology, Seoul National University Metropolitan Government;Boramae Hospital, Seoul, Republic of Korea. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36214181/ |
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