| アブストラクト | STUDY OBJECTIVE: To estimate the prevalence of congenital anomalies between the offspring of women exposed and unexposed to asthma drugs during early pregnancy. DESIGN: Matched cohort study. DATABASE: The United Kingdom's General Practice Research Database. PATIENTS: Women exposed to asthma drugs during early pregnancy and a sample of matched unexposed pregnant women. MEASUREMENTS AND MAIN RESULTS: The prevalence of any anomaly among unexposed and exposed women was 27.8 (95% confidence interval [CI] 25.4-30.6)/1000 pregnancies and 31.3 (95% CI 27.7-35.5)/1000 pregnancies, respectively (relative risk [RR] 1.1 95% CI 1.0-1.3). CONCLUSION: Our findings suggest that asthma drugs, overall, do not increase the risk of congenital anomalies in the offspring when taken during the first trimester of pregnancy. |
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| ジャーナル名 | Pharmacotherapy |
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| Pubmed追加日 | 2013/3/2 |
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| 投稿者 | Vasilakis-Scaramozza, Catherine; Aschengrau, Ann; Cabral, Howard J; Jick, Susan S |
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| 組織名 | Department of Epidemiology, Boston University School of Public Health, Boston,;MA, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/23450814/ |
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