| アブストラクト | Atypical femur fracture (AFF) is a rare but catastrophic adverse event first reported in the long-term use of alendronate, one of the most commonly used drugs for osteoporosis currently. However, further evidence is needed to learn more regarding other common anti-osteoporosis drugs and the risk for AFF. In this study, reports of AFF were identified from Food and Drug Administration Adverse Event Reporting System database. Disproportionality analyses were performed to examine the reporting odds ratio (ROR), information component (IC) and adjusted ROR (adj. ROR) signals for AFF for common anti-osteoporosis drugs. A total of 1692 unique AFF reports were identified. The disproportionality signals (the lower bound of 95% confidence interval > 1 for ROR and adjusted ROR, and > 0 for IC) were detected for alendronate, denosumab, pamidronate, risedronate, zoledronate, ibandronate, and teriparatide while no signal was detected for raloxifene, abaloparatide, and romosozumab. When restricted in patients with osteoporosis, the disproportionality signals were still detected for alendronate, pamidronate, risedronate, denosumab, and ibandronate. Our results suggest that alendronate has the largest risk signal, while the risks varied among different bisphosphonates. In addition, denosumab was found statistically associated with AFF in both the entire database and patients with osteoporosis. |
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| ジャーナル名 | Scientific reports |
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| 投稿日 | 2023/7/6 |
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| 投稿者 | Xiao, Yao; Chen, Yiqian; Huang, Yan; Xiao, Yuan |
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| 組織名 | Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of;Central South University, Changsha, 410008, Hunan, China.;Department of Gastroenterology, Xiangya Hospital of Central South University,;Changsha, 410008, Hunan, China.;xiaoyuan2021@csu.edu.cn.;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital,;Changsha, 410008, Hunan, China. xiaoyuan2021@csu.edu.cn. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37407650/ |
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