| アブストラクト | BACKGROUND: Shoulder injury related to vaccine administration (SIRVA) may result from improper vaccination technique when a vaccine is given into or near the subacromial bursa or synovium, which may result in shoulder pain, dysfunction, and long-lasting impairment. METHODS: We searched the Vaccine Adverse Event Reporting System for reports received January 1, 2018, through October 31, 2022, describing atypical shoulder pain and dysfunction. We used the National Vaccine Injury Compensation Program's definition for SIRVA: onset within 48 h after vaccination, with pain and decreased range of motion in the vaccinated arm. We added the requirement that symptoms last >/= 7 days. RESULTS: Based on automated search, 26 061 (2.4%) were potential cases. In reviewing all 1819 serious and a random sample of 200 nonserious reports, 580 (32%) serious and 38 (19%) nonserious reports were potential SIRVA cases for a reporting rate of approximately 0.5%. SIRVA was rare in children and serious reports were most frequent among adult females (74%). A contributing factor was vaccine given "too high" in the arm in 68%. Interference/inability to perform activities of daily living and/or absenteeism from work was reported in 285 (64%) serious reports. CONCLUSIONS: SIRVA is a rarely reported but important vaccine adverse event; symptoms can impact activities of daily living and work. Its greater frequency in female sex, rarity in children, and the association with the vaccine administered too high in the arm are consistent with previous studies. Prevention strategies should be prioritized, including vaccinator training to adhere to proper vaccine administration techniques. |
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| ジャーナル名 | Pharmacoepidemiology and drug safety |
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| Pubmed追加日 | 2026/5/15 |
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| 投稿者 | Miller, Elaine R; Marquez, Paige; Aynalem, Getahun; Licata, Charles; Rubin, Mary Nythel; Freeborn, Emma; Davis, Shaeyla; Roberts, Amy; Poudyal, Manisha; Kim, Sehwa S; Cooper, Heather; Rounds, Monica; Mozingo, Liza; Amouzou, Sandra; Zhang, Bicheng; Dunbar, Sara; Caraballo, Valerie; Barre, Aisha; McVey, Rachel; Stibbe, Caitlin; Harris, Margaret; Davis, Jennifer; Ramirez, Vanessa; Lemperle, Michael; Moro, Pedro L |
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| 組織名 | Immunization Safety Office, Division of Healthcare Quality Promotion, National;Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control;and Prevention, Atlanta, Georgia, USA.;Office of Biostatistics and Pharmacovigilance, Center for Biologics Evaluation;and Research, Food and Drug Administration, Silver Spring, Maryland, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42135986/ |
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